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Displaying results 1491 - 1500 of 10000 in total
  1. Drug

    Tepotinib

    go.drugbank.com/drugs/DB15133
    ApprovedInvestigational

    In February 2022, tepotinib was approved for use in Europe.[L42200] … [A228058] MET is a desirable target in the treatment of certain solid tumors as it appears to play a critical role, both directly and indirectly, in the growth and proliferation of tumors in which it is

    Categories: MATE 1 Inhibitors, MATE 2 Inhibitors
  2. Drug

    Thyroid, porcine

    go.drugbank.com/drugs/DB09100
    ApprovedInvestigational

    [A190831] Thyroid extract is no longer considered a first line therapy as it delivers a dose that is inconsistent with the stated strength of the tablet. … [A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891[A190807] but its use dates back as far as the 6th century.

    Categories: Agents used to treat hypothyroidism
  3. Drug

    LX-7101

    go.drugbank.com/drugs/DB16009
    Investigational

    LX-7101 is under investigation in clinical trial NCT01528111 (Study to Evaluate the Safety, Tolerability, and Efficacy of LX7101 in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension).

    Categories: Heterocyclic Compounds, 1-Ring
  4. Pathway

    Non-Ketotic Hyperglycinemia

    smpdb.ca/view/SMP0000223
    Disease

    Non Ketotic Hyperglycinemeia (Glycine encephalopathy; Glycine cleavage system deficiency; NKH) is caused by mutations in several genes in the mitochondrial glycine cleavage system. These include the genes encoding P protein (GLDC), T pro...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
    Enzymes: Betaine--homocysteine S-methyltransferase 1
  5. Pathway

    3-Phosphoglycerate Dehydrogenase Deficiency

    smpdb.ca/view/SMP0000721
    Disease

    3-Phosphoglycerate dehydrogenase deficiency is a disorder of L-serine biosynthesis that is characterized by congenital microcephaly, psychomotor retardation, and seizures.The disorder is caused by homozygous or compound heterozygous or h...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
    Enzymes: Betaine--homocysteine S-methyltransferase 1
  6. Pathway

    Nilotinib Inhibition of BCR-ABL Action Pathway

    smpdb.ca/view/SMP0031697
    Drug action

    Nilotinib is a tyrosine kinase inhibitor used to treat chronic myelogenous leukemia (CML), a cancer characterized by increased and unregulated growth of white blood cells in the bone marrow and the accumulation of these cells in the bloo...

    Drugs: Nilotinib
    Enzymes: S-phase kinase-associated protein 2
  7. Pathway

    Asciminib Inhibition of BCR-ABL

    smpdb.ca/view/SMP0126943
    Drug action

    Asciminib is an inhibitor of ABL/BCR-ABL1 tyrosine kinase for the treatment of patients with Philadelphia chromosome-positive CML, including those with the T315I mutation. Asciminib is an allosteric inhibitor of the BCR-ABL1 tyrosine kin...

    Drugs: Asciminib
    Enzymes: S-phase kinase-associated protein 2
  8. Drug

    Influenza A virus A/Brisbane/02/2018 IVR-190 (H1N1) antigen (formaldehyde inactivated)

    go.drugbank.com/drugs/DB15515
    Approved

    A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy the virus as there are circulating antibodies that recognize that particular component of the virus

    Mixtures: INFLUVAC S, INFLUVAC SSynonyms: Influenza A virus A/Brisbane/02/2018 IVR-190 (H1N1) antigen (formaldehyde inactivated)
  9. Pathway

    Dimethylglycine Dehydrogenase Deficiency

    smpdb.ca/view/SMP0000484
    Disease

    Dimethylglycine dehydrogenase deficiency, also called DMGDH deficiency and dimethylglycinuria, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of glycine metabolism caused by a defective DMGDH gene. DMGDH code...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
    Enzymes: Betaine--homocysteine S-methyltransferase 1
  10. Pathway

    Dasatinib Inhibition of BCR-ABL Action Pathway

    smpdb.ca/view/SMP0031696
    Drug action

    Dasatinib is a tyrosine kinase inhibitor used to treat chronic myelogenous leukemia (CML), a cancer characterized by increased and unregulated growth of white blood cells in the bone marrow and the accumulation of these cells in the bloo...

    Drugs: Dasatinib
    Enzymes: S-phase kinase-associated protein 2