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Displaying results 151 - 160 of 167 in total
  1. Target

    Angiopoietin-1

    go.drugbank.com/bio_entities/BE0010681
    TargetHumans

    Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. … kinase and the AKT1 signaling cascades.

    Synonyms: ANG-1
  2. Target

    Aminoglycoside nucleotidyltransferase (4')

    go.drugbank.com/bio_entities/BE0003547
    EnzymeStaphylococcus aureus

    Inactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.

    Synonyms: ANT(4')
  3. Target

    Angiopoietin-related protein 3

    go.drugbank.com/bio_entities/BE0010034
    TargetHumans

    The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface … Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed:12565906).

    Synonyms: ANG-5
  4. Target

    Natriuretic peptides B

    go.drugbank.com/bio_entities/BE0000979
    TargetHumans

    Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed … Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:1672777, PubMed:17349887, PubMed:17372040, PubMed

    Synonyms: Iso-ANP
  5. Target

    ADP/ATP translocase 3

    go.drugbank.com/bio_entities/BE0000624
    TargetHumans

    production and cause mitochondrial thermogenesis (By similarity). … ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).

    Synonyms: ANT 2, ANT 3
  6. Target

    Eph receptors

    go.drugbank.com/bio_entities/BE0028186
    TargetHumans

    Binds to EFNA3, EFNA4 and EFNA5 … Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC.

    Synonyms: EPH- and ELK-related kinase
  7. Target

    Junction plakoglobin

    go.drugbank.com/bio_entities/BE0009084
    TargetHumans

    The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. … Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).

    Synonyms: Catenin gammaFunction: alpha-catenin binding
  8. Target

    Atrial natriuretic peptide receptor 1

    go.drugbank.com/bio_entities/BE0000556
    TargetHumans

    and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499) … Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499).

    Synonyms: ANP-A
  9. Target

    Atrial natriuretic peptide receptor 2

    go.drugbank.com/bio_entities/BE0000997
    TargetHumans

    Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth

    Synonyms: ANP-B
  10. Target

    Atrial natriuretic peptide receptor 3

    go.drugbank.com/bio_entities/BE0002426
    TargetHumans

    May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. … Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP.

    Synonyms: ANP-C