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Ganaxolone Action Pathway
smpdb.ca/view/SMP0126153Drug actionGanaxolone belongs to a novel class of neuroactive steroids sometimes referred to as "epalons", which are potent and specific positive allosteric modulators of γ-aminobutyric acid type A (GABAA) receptors
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 moreEnzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Thiocolchicoside Action Pathway (New)
smpdb.ca/view/SMP0125071Drug actionGamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the human cortex. GABAergic neurons are involved in myorelaxation, anxiolytic treatment, sedation, and anesthetics. … Thiocolchicoside has a selective and potent affinity for g-aminobutyric acid A (GABA-A) receptors and acts on muscular contractures by activating the GABA inhibitory pathways thereby behaving as a potent
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +2 moreEnzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Estazolam Action Pathway
smpdb.ca/view/SMP0126125Drug actionAs benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects GABA by increasing GABA affinity for the GABA receptor.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Flunitrazepam Action Pathway
smpdb.ca/view/SMP0126128Drug actionAs benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Flunitrazepam +3 moreEnzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Ketazolam Action Pathway
smpdb.ca/view/SMP0126132Drug actionAs benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. … Benzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA), which results in sedative, hypnotic, anxiolytic, anticonvulsant, muscle relaxant and amnesic action.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Lormetazepam Action Pathway
smpdb.ca/view/SMP0126133Drug actionLormetazepam, as a benzodiazepine, binds to the regulatory site between the α and γ subunits of γ-aminobutryic acid (GABA) A receptors with γ2 and α1, α2, α3, or α5 subunits.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +2 moreEnzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Quazepam Action Pathway
smpdb.ca/view/SMP0126138Drug actionLike other benzodiazepines, quazepam likely exerts its effects by potentiating the effect of gamma-aminobutyric acid (GABA) on GABA(A) receptors, the main inhibitory neurotransmitter receptors in the mammalian
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Remimazolam Action Pathway
smpdb.ca/view/SMP0126145Drug actionLike other benzodiazepines, remimazolam exerts its therapeutic effects by potentiating the effect of gamma-aminobutyric acid (GABA) on GABA(A) receptors, the main inhibitory neurotransmitter receptors
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +2 moreEnzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Talbutal Action Pathway
smpdb.ca/view/SMP0126147Drug actionTalbutal, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate duration of action. It is a nonselective central nervous system (CNS) depressant.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Nitrazepam Action Pathway
smpdb.ca/view/SMP0126164Drug actionThis drug affects central benzodiazepine receptors, which are associated with inhibitory GABA (gamma amino butyric acid)receptors, leading to enhanced GABA binding activity.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2