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Trandolapril Metabolism Pathway
smpdb.ca/view/SMP0000599Drug metabolismTrandolapril (trade name: Mavik) belongs to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can also be used in the treatment of cong...
Gemcitabine Metabolism Pathway (old)
smpdb.ca/view/SMP0000603Drug metabolismGemcitabine is a cytidine analogue used in the treatment of certain cancers. Gemcitabine enters the cell via sodium nucleoside co-transporters (SLC29A1, SLC28A1, and SLC28A3), where it acts through multiple mechanisms to produce a cytoto...
Felbamate Metabolism Pathway
smpdb.ca/view/SMP0000633Drug metabolismFelbamate is metabolized in the liver. One route of metabolism consists of the hydroxylation to 2-hydroxyfelbamate or p-hydroxyfelbamate, which is catalyzed by CYP2E1 and CYP3A4. Moreover, felbamate can be transformed to 2-phenyl-2-propa...
Pancreas Function
smpdb.ca/view/SMP0000643PhysiologicalThe pancreas is a glandular organ in the digestive system and endocrine system of vertebrates. It is both an endocrine gland producing several important hormones, including insulin, glucagon, somatostatin, and pancreatic polypeptide, and...
Celecoxib metabolism Pathway
smpdb.ca/view/SMP0000644MetabolicCelecoxib, a non-steroidal anti-inflammatory drug (NSAID), is a selective inhibitor of cyclooxygenase-2 (COX-2), also known as prostaglandin G/H synthase 2. Like other NSAIDs, celecoxib exerts its effects by inhibiting the synthesis of p...
Phenindione Action Pathway
smpdb.ca/view/SMP0000655Drug actionPhenindione is a medication that is used as an anticoagulant. Anticoagulants are drugs that prevent the blood from coagulating and creating blood clots. It is used to treat a variety of conditions, including cerebral and pulmonary emboli...
Carteolol Action Pathway
smpdb.ca/view/SMP0000658Drug actionCarteolol (also known as Cartrol or Ocupress) is a selective β1 adrenergic receptor antagonist (beta blocker), which can be used for treatment of high blood pressure (hypertension) and irregular heartbeats (arrhythmias). Carteolol a...
Timolol Action Pathway
smpdb.ca/view/SMP0000659Drug actionTimolol is a beta blocker medication, making it part of the antihypertensive drug class. It relieves symptoms such as tachycardia, vascular headaches, hypertension, angina and tremors. Timolol, much like propranolol or oxprenolol, begins...
Dobutamine Action Pathway
smpdb.ca/view/SMP0000662Drug actionDobutamine is a type of medication that can be used for treating heart failure and cardiogenic shock. Dobutamine can bind to beta-1 adrenergic receptor on the heart cell which lead to mild chronotropic, arrhythmogenic, hypertensive and v...
Levobunolol Action Pathway
smpdb.ca/view/SMP0000666Drug actionLevobunolol (also known as Betagan) is an ophthalmic beta blocker (non-selective) that can produce cardiovascular effects and systemic pulmonary effects. Levobunolol bind to beta1-adrenergic and beta2-adrenergic receptors in heart and va...