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Displaying results 151 - 160 of 178 in total
  1. Target

    Alpha-2 adrenergic receptors

    go.drugbank.com/bio_entities/BE0004864
    TargetHumans

    Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release (PubMed:2164221). … Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release (PubMed:2842764).

  2. Target

    Sodium channel protein

    go.drugbank.com/bio_entities/BE0004901
    TargetHumans

    For instance, it controls the release of serotonin/5-hydroxytryptamine by enterochromaffin cells and is required for both glucagon- and glucose-induced insulin secretion in pancreatic endocrine cells (

  3. Target

    5'-AMP-activated protein kinase

    go.drugbank.com/bio_entities/BE0004907
    TargetTransporterHumans

    Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (PubMed:25687571). … Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity).

  4. Target

    Solute carrier family 2, facilitated glucose transporter member 12

    go.drugbank.com/bio_entities/BE0005222
    TransporterHumans

    Insulin-independent facilitative glucose transporter

  5. Target

    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

    go.drugbank.com/bio_entities/BE0005459
    TargetHumans

    Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion (PubMed:7961800, PubMed:8253715).

  6. Target

    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    go.drugbank.com/bio_entities/BE0005530
    TargetHumans

    May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue.

  7. Target

    Serine/threonine-protein kinase TBK1

    go.drugbank.com/bio_entities/BE0009394
    TargetHumans

    Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity).

  8. Target

    Glycogen synthase kinase-3 alpha

    go.drugbank.com/bio_entities/BE0009446
    TargetHumans

    May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). … Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350).

  9. Target

    Inhibitor of nuclear factor kappa-B kinase subunit epsilon

    go.drugbank.com/bio_entities/BE0009450
    TargetHumans

    Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity).

  10. Target

    Serine/threonine-protein kinase PAK 1

    go.drugbank.com/bio_entities/BE0009505
    TargetHumans

    Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945).