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Displaying results 1601 - 1610 of 10000 in total
  1. Drug

    Midazolam

    go.drugbank.com/drugs/DB00683
    ApprovedIllicitInvestigational

    [A257153] Midazolam is considered a schedule IV drug in the United States due to the low potential for abuse and low risk of dependence.[L5074] … and endoscopic procedures as pre-anesthetic medication, and as an adjunct to local anesthesia.

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: SEDEVER 5 MG/5 ML REKTAL UYGULAMA VE IV/IM ENJEKSİYON VE İNFÜZYON İÇİN ÇÖZELTİ, 5 ADET, SEDEVER 5 MG/5 ML REKTAL UYGULAMA VE IV/IM ENJEKSİYON VE İNFÜZYON İÇİN ÇÖZELTİ ,10 ADET
  2. Drug

    Candesartan cilexetil

    go.drugbank.com/drugs/DB00796
    ApprovedInvestigational

    It is administered orally as the prodrug, candesartan cilexetil, which is rapidly converted to its active metabolite, candesartan, during absorption in the gastrointestinal tract. … Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension.

    Mixtures: CANDESARTAN E IDROCLOROTIAZIDE EG, CANDESARTAN E IDROCLOROTIAZIDE EGCategories: Agents Acting on the Renin-Angiotensin System, Angiotensin 2 Receptor Blocker
  3. Drug

    Beclomethasone dipropionate

    go.drugbank.com/drugs/DB00394
    ApprovedInvestigational

    [A180010] Compared to earlier corticosteroids such as [dexamethasone] and [prednisolone], beclomethasone dipropionate is reported to be less irritating to the nasal mucosa with a longer duration of action … [L6871] It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP)[A179839] which acts on the glucocorticoid receptor to mediates its therapeutic action.

    Synonyms: (11β,16β)-9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione, 9-chloro-11β-hydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionateInternational brands: Clenil-A
  4. Drug

    Pegsitacianine

    go.drugbank.com/drugs/DB19098
    Investigational

    Pegsitacianine is under investigation in clinical trial NCT05576974 (A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence … Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)).

  5. Drug

    RUS 3108

    go.drugbank.com/drugs/DB05911
    Experimental

    The drug’s Phase I clinical trials have been initiated in Europe to assess safety of the drug compound in healthy volunteers. … RUS 3108 is being developed for the treatment of atherosclerosis, the major cause of cardiovascular disorders such as heart attacks and stroke by Dr. Reddy’s Laboratories.

  6. Drug

    Azelastine

    go.drugbank.com/drugs/DB00972
    ApprovedInvestigational

    Azelastine, a phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic … [L8240,L8270] Azelastine is also available in combination with fluticasone propionate as a nasal spray marketed under the trade name Dymista™, which is indicated for the symptomatic treatment of seasonal

    Mixtures: N-S-4, ALERXY® CCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  7. Drug

    Epinastine

    go.drugbank.com/drugs/DB00751
    Approved

    It has a multi-action effect that inhibits the allergic response in 3 ways: 1. stabilizes mast cells by preventing mast cell degranulation to control the allergic response, 2. prevents histamine binding … to both the H1- and H2-receptors to stop itching and provide lasting protection, and 3. prevents the release of proinflammatory chemical mediators from the blood vessel to halt progression of the allergic

    Mixtures: FLURINOL(R) D COMPRIMIDOS DE LIBERACION MODIFICADACategories: Cytochrome P-450 Substrates, P-glycoprotein substrates
  8. Pathway

    Intracellular Signalling Through Adenosine Receptor A2a and Adenosine

    smpdb.ca/view/SMP0000320
    Signaling

    The adenosine receptor A2a activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates

    Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  9. Drug

    Enzacamene

    go.drugbank.com/drugs/DB11219
    Approved

    It is used in cosmetic products such as sunscreen to provide skin protection against UV rays. … While its effects on the human reproductive system as an endocrine disruptor are being investigated, its use in over-the-counter and cosmetic products is approved by Health Canada.

    Mixtures: Anthelios S - Ecran Solaire SPF 30, Bain De Soleil Protection Lotion SPF 15Synonyms: Enzacamene D-L form, 3-(4-methylbenzylidene)camphor
  10. Drug

    Sodium phosphate, dibasic, unspecified form

    go.drugbank.com/drugs/DB14504
    Approved

    Mixtures: Isolyte S pH 7.4, gent-L-tip