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Chondroitin sulfate
go.drugbank.com/drugs/DB09301ApprovedInvestigationalNutraceutical[A32063] Chondroitin sulfate is sold as an OTC dietary supplement in North America and it is a prescription drug under the EMA in Europe.[A32066] … Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine and 1,4-β-d-glucuronic acid units which bear 4-O- and/or 6-O-sulfations at the N-acetylgalactosamine units disposed of in specific
Mixtures: flexijoint 3-in-1 Joint Care Powder, OSTEOACTIV 3-in-1 Joint Formula PowderProducts: Nn Bio Chondroitin 400, Kordel"s Chondroitin 400mgInfigratinib
go.drugbank.com/drugs/DB11886ApprovedInvestigationalWithdrawncholangiocarcinoma in adults with a fibroblast growth factor receptor 2 (FGFR2) fusion or another rearrangement as detected by an FDA-approved test. … [A198963] Infitratinib is a pan-FGFR inhibitor, as it is an ATP-competitive inhibitor of all four FGFR receptor subtypes.
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsAtorvastatin
go.drugbank.com/drugs/DB01076ApprovedInvestigationalAtorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. … [A181087, A181406] Atorvastatin and other statins including [lovastatin], [pravastatin], [rosuvastatin], [fluvastatin], and [simvastatin] are considered first-line treatment options for dyslipidemia
Mixtures: EZETIMIBE E ATORVASTATINA DOC, EZETIMIBE E ATORVASTATINA DOCCategories: P-glycoprotein inhibitors, P-glycoprotein substratesPilocarpine
go.drugbank.com/drugs/DB01085ApprovedInvestigationalA naturally occurring alkaloid derived from the _Pilocarpus_ plants, pilocarpine is a muscarinic acetylcholine agonist. … [A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors.
Mixtures: E-pilo-2 Oph Soln, E-pilo-6 Oph SolnCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 InhibitorsOlsalazine Action Pathway
smpdb.ca/view/SMP0126110Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase, or prostaglandin E2 via prostaglandin E synthase. … It targets the prostaglandin G/H synthase-1 (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway.
Enzymes: Prostaglandin E synthasePotassium nitrate
go.drugbank.com/drugs/DB11090ApprovedInvestigationalIn addition, potassium nitrate is used as a diuretic in pigs, cattle, and horses. It is administered orally doses up to 30 g per animal per day [L1736]. … Potassium nitrate is a common active ingredient in toothpaste, exerting an anti-sensitivity action.
Mixtures: HyVee Inc Maximum Strength, Wal-Mart Stores Inc. EquateCategories: Compounds used in a research, industrial, or household settingTeclistamab
go.drugbank.com/drugs/DB16655ApprovedInvestigational[A253587] On August 24, 2022, the European Commission (EC) granted conditional marketing authorization of teclistamab as first-in-class bispecific antibody for the treatment of multiple myeloma, marking … Teclistamab is an IgG4-PAA bispecific antibody that targets the CD3 receptor expressed on the surface of T cells and B cell maturation antigen (BCMA) expressed on malignant multiple myeloma cells.
Categories: Bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engagerRabeprazole Action Pathway
smpdb.ca/view/SMP0000229Drug actionThe pathway begins in the parietal cell in the stomach, where rabeprazole and a hydrogen ion use the active metabolite in rabeprazole —rabeprazole thioether — to inhibit potassium-transporting ATPase at … Now in the gastric endothelial cell, these secretory surfaces are inhibited by rabeprazole and by G-Protein signalling cascade through somatostatin receptor type 4, which is activated by somatostatin.
Enzymes: Potassium voltage-gated channel subfamily E member 2Pirenzepine Action Pathway
smpdb.ca/view/SMP0000246Drug actionPirenzepine (also known as Gastrozepin) is a selective antagonist (antimuscarinic) that will inhibit the muscarinic acetylcholine receptor M3 inside the stomach. Binding of pirenzepine on the receptor will decrease the level of exertion ...
Enzymes: Potassium voltage-gated channel subfamily E member 2Roxatidine Acetate Action Pathway
smpdb.ca/view/SMP0000734Drug actionThe pathway begins in the stomach, where roxatidine acetate inhibits the histamine H2 receptor on the surface of the parietal cell. … Now in the gastric endothelial cell, potassium-transporting ATPase units are inhibited by G-Protein signalling cascade through somatostatin receptor type 4, which is activated by somatostatin.
Enzymes: Potassium voltage-gated channel subfamily E member 2