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Displaying results 1671 - 1680 of 8696 in total
  1. Drug

    Olezarsen

    go.drugbank.com/drugs/DB18728
    ApprovedInvestigational

    Olezarsen is an antisense oligonucleotide that targets the messenger RNA (mRNA) for apolipoprotein C-III (APOC3, apoC-III),[L52033] which is a key regulator of triglyceride levels in plasma, in the liver … [L52033] On December 19, 2024, olezarsen was approved by the FDA for the treatment of familial chylomicronemia syndrome.[L52028] It is also being investigated for the treatment of hyperlipidemia.

    Categories: Non-statin Hypolipidemic Agents Indicated for HyperlipidemiaSynonyms: ALL-P-AMBO-5'-O-(((6-(5-((TRIS(3-(6-(2-ACETAMIDO-2-DEOXY-.BETA., -D-GALACTOPYRANOSYLOXY)HEXYLAMINO)-3-OXOPROPOXYMETHYL))METHYL)AMINO-5-OXOPENTANAMIDO)HEXYL))PHOSPHO)-2'-O-(2-METHOXYETHYL)-P-THIOADENYLYL-(3'-O->5'-O)-2'-O-(2-METHOXYETHYL)-P-THIOGUANYLYL-(3
  2. Drug

    Dosulepin

    go.drugbank.com/drugs/DB09167
    ApprovedInvestigational

    Dosulepin (INN, BAN) formerly known as dothiepin (USAN), is a tricyclic antidepressant with anxiolytic properties that is used in several European and South Asian countries, as well as Australia, South

    Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C9 Inhibitors
  3. Drug

    Tropicamide

    go.drugbank.com/drugs/DB00809
    Approved

    [A229958] It is also used in combination with [hydroxyamphetamine] for the same indication. … Tropicamide is an alkaloid atropine‐derived anticholinergic drug and a non‐selective antagonist of muscarinic acetylcholine (mACh) receptors.

    Mixtures: MYDRIA MAC, T-P OFTENO
  4. Drug

    Elacestrant

    go.drugbank.com/drugs/DB06374
    ApprovedInvestigational

    [A256828,A256863,L44948] Other types of endocrine therapy, such as selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs), may lead to drug resistance over time; therefore, the use … Elacestrant is a non-steroidal small molecule and an estrogen receptor (ER) antagonist.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  5. Drug

    Sulfamethoxazole

    go.drugbank.com/drugs/DB01015
    ApprovedInvestigational

    [L11830] In this combination, sulfamethoxazole is useful for the treatment of a variety of bacterial infections, including those of the urinary, respiratory, and gastrointestinal tracts. … which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps in the biosynthesis of nucleic acids and proteins which are necessary for

    Mixtures: MAXTRIM-P, Eusaprim orale Suspension für KinderCategories: Antibacterials for Systemic Use, Antiinfectives for Systemic Use
  6. Target

    Dopamine receptor D1

    go.drugbank.com/bio_entities/BE0000020
    TargetHumans

    Also acts as a receptor for D-lysergic (LSD) psychedelic drug (PubMed:39094559) … DRD1 can also couple with G(q) by forming a heteromer with the ghrelin receptor GHSR in hippocampal neurons independently of ghrelin (By similarity).

    Polypeptides: Dopamine receptor D1Synonyms: Dopamine D1 receptor, D(1A) dopamine receptor
  7. Target

    Growth hormone receptor

    go.drugbank.com/bio_entities/BE0000075
    TargetHumans

    Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth (PubMed:1549776, PubMed:2825030, PubMed:8943276).

    Polypeptides: Growth hormone receptorSynonyms: GH receptor, Somatotropin receptor
  8. Target

    Dopamine receptor D5

    go.drugbank.com/bio_entities/BE0000145
    TargetHumans

    G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:11500503 … Dopamine receptors can be classified in two categories: (1) DRD5 (together with DRD1) is a D1-type receptor and is coupled to G(s) G proteins, mediating activation of adenylate cyclase activity, while

    Polypeptides: Dopamine receptor D5Synonyms: D(1B) dopamine receptor, Dopamine D5 receptor
  9. Target

    Adenosine receptor A2b

    go.drugbank.com/bio_entities/BE0000241
    TargetHumans

    Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

    Polypeptides: Adenosine receptor A2bFunction: G protein-coupled adenosine receptor activity
  10. Target

    Folate receptor beta

    go.drugbank.com/bio_entities/BE0000271
    TargetTransporterHumans

    Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release

    Polypeptides: Folate receptor betaSynonyms: Folate receptor 2, Folate receptor, fetal/placental