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Displaying results 161 - 170 of 134683 in total

Pathway
MAPK/p38
smpdb.ca/view/SMP0649855
Signaling
They are activated by the MAPKK’s MKK3/MKK6 and MKK4, which are activated by MAPKKK’s. … They are proline-directed serine/threonine kinases of the mitogen-activated protein kinase (MAPK) family. This family is found in all eukaryotes for their roles in structure and regulation.
Drugs: Magnesium cation
Enzymes: Signal transducer and activator of transcription 1-alpha/beta, Mitogen-activated protein kinase 13
Pathway
Alprenolol Action Pathway
smpdb.ca/view/SMP0000297
Drug action
Without renin, angiotensin II and aldosterone could not be produced, which ultimately prevent water retention and vasoconstriction. … Blocking beta-1 adrenergic receptor could prevent the binding of epinephrine and norepinephrine, which could efficiently reduce blood pressure and heart rate.
Drugs: ATP · Alprenolol · Potassium cation · Calcium
Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
Pathway
Betaxolol Action Pathway
smpdb.ca/view/SMP0000299
Drug action
Blocking of beta1-adrenergic receptors in heart and vascular smooth muscle can lead to reduced heart rate, cardiac output, and decreased blood pressure. … Betaxolol (also known as Betoptic or Lokren) is a selective beta blocker that can block beta1-adrenergic receptors and beta2-adrenergic receptors.
Drugs: ATP · Betaxolol · Potassium cation · Calcium
Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
Pathway
Esmolol Action Pathway
smpdb.ca/view/SMP0000301
Drug action
Normally, epinephrine and norepinephrine bind to the beta-1 adrenergic receptor with equal affinity and trigger a G-protein signalling cascade that result in the heart muscle contracting. … Esmolol is injected intravenously, and when it enters the heart, it binds to the beta-1 adrenergic receptor, preventing signalling.
Drugs: ATP · Esmolol · Potassium cation · Calcium
Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
Pathway
Nadolol Action Pathway
smpdb.ca/view/SMP0000303
Drug action
heart rate and cardiac output. … In juxtaglomerular apparatus, nadolol can prevent the production of aldosterone and angiotensin II by inhibiting renin production, which lead to prevention of water retention and vasoconstriction.
Drugs: ATP · Nadolol · Potassium cation · Calcium
Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
Pathway
Oxprenolol Action Pathway
smpdb.ca/view/SMP0000304
Drug action
, heart rate and cardiac output. … In juxtaglomerular apparatus, oxprenolol can prevent the production of aldosterone and angiotensin II by inhibiting renin production, which lead to prevention of water retention and vasoconstriction.
Drugs: ATP · Potassium cation · Calcium · Oxprenolol
Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
Pathway
Propranolol Action Pathway
smpdb.ca/view/SMP0000307
Drug action
Propranolol binding reduces resting heart rate, cardiac output, blood pressure and orthostatic hypotension. Propranolol also reduce sympathetic activity to manage hyperthyroidism, anxiety and tremor. … Propranolol also competes for beta(2)-adrenergic receptors on bronchial and vascular smooth muscles.
Drugs: ATP · Propranolol · Potassium cation · Calcium
Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
Pathway
Quinidine Action Pathway
smpdb.ca/view/SMP0000323
Drug action
Sodium channels then close and rapidly activated potassium channels such as the voltage-gated transient outward delayed rectifying potassium channel (I-Kto) and the voltage-gated ultra rapid delayed rectifying … Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium
Drugs: ATP · Quinidine · Potassium cation · Calcium
Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
Pathway
Disopyramide Action Pathway
smpdb.ca/view/SMP0000325
Drug action
Sodium channels then close and rapidly activated potassium channels such as the voltage-gated transient outward delayed rectifying potassium channel (I-Kto) and the voltage-gated ultra rapid delayed rectifying … Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium
Drugs: ATP · Disopyramide · Potassium cation · Calcium
Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
Pathway
Nebivolol Action Pathway
smpdb.ca/view/SMP0000366
Drug action
Nebivolol competes with epinephrine or other beta-1 adrenergic receptor activator to bind on the receptor, which can reduce the heart rate and blood pressure that could caused by biniding of epinephrine … Nebivolol (also known as Bystolic or Nebivololum) is a Î²1-receptor blocker (selective Î²1-receptor antagonist) that can bind and inhibit Beta-1 adrenergic receptor in muscule and heart.
Drugs: ATP · Potassium cation · Calcium · Nebivolol
Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4