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DNA topoisomerase 2-alpha
go.drugbank.com/bio_entities/BE0000742TargetHumansstrand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612, PubMed:27754753). … Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken
Synonyms: TOP2Eph receptors
go.drugbank.com/bio_entities/BE0028186TargetHumansBinds to EFNA3, EFNA4 and EFNA5 … Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3
Synonyms: EPH- and ELK-related kinasePyruvate Kinases
go.drugbank.com/bio_entities/BE0009686EnzymeTargetHumansThe transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263) … Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis (PubMed:11960989).
Synonyms: OIP-3DNA topoisomerase 2
go.drugbank.com/bio_entities/BE0004951TargetHumansstrand, and religating the broken strand. … strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612, PubMed:27754753).
Synonyms: TOP2Protein RIC-3
go.drugbank.com/bio_entities/BE0009005TargetHumansMolecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors (PubMed:12821669, PubMed:15504725, PubMed … May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4
Synonyms: Resistant to inhibitor of cholinesterase 3Atrial natriuretic peptide receptor 1
go.drugbank.com/bio_entities/BE0000556TargetHumansand subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499) … Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499).
Synonyms: ANP-AAtrial natriuretic peptide receptor 2
go.drugbank.com/bio_entities/BE0000997TargetHumansReceptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth
Synonyms: ANP-BAtrial natriuretic peptide receptor 3
go.drugbank.com/bio_entities/BE0002426TargetHumansActs as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production … May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects.
Synonyms: ANP-COuter membrane protein TolC
go.drugbank.com/bio_entities/BE0001931TargetTransporterEscherichia coli (strain K12)Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. … These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.
Synonyms: tocKiller cell immunoglobulin-like receptor 2DL2
go.drugbank.com/bio_entities/BE0010848TargetHumansReceptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis
Synonyms: p58 natural killer cell receptor clone CL-43