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Imipramine
go.drugbank.com/drugs/DB00458ApprovedInvestigationalIn depressed individuals, imipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. … They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Combined Inhibitors of Serotonin/Norepinephrine ReuptakeSynonyms: 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine, N-(γ-dimethylaminopropyl)iminodibenzylDabocemagene autoficel
go.drugbank.com/drugs/DB17878InvestigationalDeveloped by Castle Creek Biosciences Inc., dabocemagene autoficel is being investigated for the treatment of dystrophic epidermolysis bullosa.[L46797] … Dabocemagene autoficel is an _ex vivo_, autologous cell-based gene therapy. It comprises autologous dermal fibroblasts genetically modified to express functional type VII collagen.
Synonyms: D-Fi, THE CONTROL OF A HUMAN CYTOMEGALOVIRUS (CMV) PROMOCabazitaxel
go.drugbank.com/drugs/DB06772ApprovedInvestigational[A260421] It was also approved by the EMA on March 17, 2011 [L47381] and Health Canada on December 17, 2019.[L47376] … [A7056, A260421, A260621] Cabazitaxel is used to treat metastatic castration-resistant prostate cancer. It was first approved by the FDA on June 17, 2010.
Synonyms: 1-HYDROXY-7.BETA.,10.BETA.-DIMETHOXY-9-OXO-5.BETA.,20-EPOXYTAX-11-ENE-2.ALPHA.,4,13.ALPHA.-TRIYL 4-ACETATE 2-BENZOATE 13-((2R,3S)-3-(((TERT-BUTOXY)CARBONYL)AMINO)-2-HYDROXY-3-PHENYLPROPANOATE)Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic IndexMultiple Endocrine Neoplasia
go.drugbank.com/conditions/DBCOND0028176Synonyms: Polyglandular activity in multiple endocrine adenomatosis, Polyglandular activity in multiple endocrine adenomatosis (disorder)Tioconazole
go.drugbank.com/drugs/DB01007ApprovedTioconazole is an imidazole antifungal used to treat fungal and yeast infections. Topical formulations are used for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". … In addition to being an antifungal, tioconazole also has antibacterial effects on certain Gram-positive cocci bacteria.[L50166]
Mixtures: Gynecure Tandempk.vag Ov.300mg/vulv.crm1%w/w, Gynecure Tandempk.vag Ov.300mg/vulv.crm1%w/wCategories: combinations of imidazole derivatives, Metabolic Side Effects of Drugs and SubstancesFungal infections of the cornea
go.drugbank.com/conditions/DBCOND0104097Drugs: NatamycinSynonyms: Fungal infections in the corneaEstradiol
go.drugbank.com/drugs/DB00783ApprovedInvestigationalVet approvedEstradiol is a naturally occurring hormone circulating endogenously in females. … Because it has a low oral bioavailability on its own, estradiol is commonly formulated with an ester side-chain.
Mixtures: HelloPharmacist Bi-EST 5.0 Cream, KLIOGEST NCategories: Sex Hormones and Modulators of the Genital System, P-glycoprotein substratesDipyridamole
go.drugbank.com/drugs/DB00975ApprovedInvestigationalA phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin.
Mixtures: AGGRENOX ® CAPSULAS DE LIBERACION RETARDADACategories: P-glycoprotein inhibitors, P-glycoprotein substratesLevosalbutamol
go.drugbank.com/drugs/DB13139ApprovedLevosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). … [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer.
Categories: Agents to Treat Airway Disease, Adrenergic beta-2 Receptor AgonistsSynonyms: R-salbutamol, (R)-salbutamol