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Nitrofurantoin
go.drugbank.com/drugs/DB00698ApprovedInvestigationalVet approved[A179824] Nitrofurantoin is a second line treatment to [trimethoprim]/[sulfamethoxazole].[A179830] Nitrofurantoin was granted FDA approval on 6 February 1953.[L6895] … Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections.
Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingSynonyms: N-(5-Nitrofurfurylidene)-1-aminohydantoin, 1-((5-nitro-2-furanyl)methylene)amino-2,4-imidazolidenedioneNiraparib
go.drugbank.com/drugs/DB11793ApprovedInvestigational[L43277] Niraparib is selective towards PARP-1 and PARP-2. … Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells.
Categories: MATE 1 Substrates with a Narrow Therapeutic Index, MATE 2 Substrates with a Narrow Therapeutic IndexGamolenic acid
go.drugbank.com/drugs/DB13854ApprovedWithdrawnGamolenic acid may be found in over-the-counter dietary supplements. Gamolenic acid is also found in some fungal sources and also present naturally in the form of triglycerides [F27]. … Gamolenic acid is produced minimally in the body as the delta 6-desaturase metabolite of [DB00132]. It is converted to [DB00154], a biosynthetic precursor of monoenoic prostaglandins such as PGE1.
Mixtures: PRIM E CAPSULE, Evening Primrose Oil Cap 500mg W Vit ECategories: Fatty Acids, Omega-6Ertugliflozin
go.drugbank.com/drugs/DB11827ApprovedInvestigationalErtugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. … [A31581] Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018.[L48621]
Categories: Drugs Used in Diabetes, P-glycoprotein substratesSynonyms: 1,6-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-β-L-idopyranose, β-L-Idopyranose, 1,6-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-Streptococcus pneumoniae type 18c capsular polysaccharide antigen
go.drugbank.com/drugs/DB10335ApprovedInvestigationalStreptococcus pneumoniae type 18c capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 18c of *Streptococcus pneumoniae … It is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia.
Mixtures: PNEUMOVAX 23 Injektionslösung in einer Fertigspritze, PNEUMOVAX 23 Injektionslösung in einer DurchstechflascheUlipristal
go.drugbank.com/drugs/DB08867ApprovedInvestigationalUlipristal is currently recommended as first line therapy for emergency contraception, due to improved efficacy and similar side effect profile as compared to the traditional use of levonorgestrel or the … It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: ESMYA® 5 MG COMPRIMIDOS, เอสมายาชนิดเม็ด 5 มก.Alclometasone Action Pathway
smpdb.ca/view/SMP0126158Drug actionAlclometasone is a synthetic glucocorticoid steroid for topical use in the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Enzymes: Prostaglandin E synthaseClobetasol propionate Action Pathway
smpdb.ca/view/SMP0126191Drug actionClobetasol propionate is a corticosteroid derived from prednisolone but with a higher specificity for glucocorticoid receptors than mineralocorticoid receptors. It is used to treat corticosteroid-responsive dermatoses and moderate to sev...
Drugs: Glutathione · Dinoprostone · Clobetasol propionate · Calcium · Prostaglandin D2 · Mesoheme +2 moreEnzymes: Prostaglandin E synthaseDesoximetasone Action Pathway
smpdb.ca/view/SMP0126224Drug actionDesoximetasone, also known as Desoxi or Topicort, is a topical anti-inflammatory glucocorticoid used to treat corticosteroid-responsive dermatoses. Desoximetasone is a selective glucocorticoid receptor agonist. By binding to the glucocor...
Enzymes: Prostaglandin E synthaseDiflorasone Action Pathway
smpdb.ca/view/SMP0126227Drug actionThis drug is used in the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Diflorasone is a selective glucocorticoid receptor agonist.
Enzymes: Prostaglandin E synthase