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Displaying results 1741 - 1750 of 10000 in total
  1. Drug

    Medroxyprogesterone acetate

    go.drugbank.com/drugs/DB00603
    ApprovedInvestigational

    Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. … manage pain in endometriosis, prevent pregnancy, and is also used in palliative care for endometrial and renal carcinoma.

    Mixtures: OBAT SUNTIK KB II, DIVICONT TABLETAS 1 MG/5 MGCategories: Pregnen (4) Derivatives, P-glycoprotein inhibitors
  2. Drug

    Alfentanil

    go.drugbank.com/drugs/DB00802
    ApprovedIllicitInvestigational

    A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. … Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide
  3. Pathway

    Simvastatin Predicted Metabolism Pathway

    smpdb.ca/view/SMP0174691
    Metabolic

    Metabolites of Simvastatin are predicted with biotransformer.

    Drugs: Simvastatin · Mesoheme
  4. Drug

    Promethazine

    go.drugbank.com/drugs/DB01069
    ApprovedInvestigational

    Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. … [A189901] Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.

    Mixtures: PROMEDYL-B LINCTUS, COPHADYL-E COUGH LINCTUSCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  5. Indication

    Decreased appetite

    go.drugbank.com/conditions/DBCOND0012116
    Drugs: Bromopride · Rhubarb
    Synonyms: Decrease in appetite (finding)
  6. Indication

    Relapsed Acute Lymphoblastic Leukemia (ALL)

    go.drugbank.com/conditions/DBCOND0069491
    Drugs: Clofarabine · Vincristine
    Synonyms: Acute Lymphoblastic Leukemia, in Relapse
  7. Drug

    Isoflurane

    go.drugbank.com/drugs/DB00753
    ApprovedInvestigationalVet approved

    A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersSynonyms: 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether
  8. Drug

    Clotrimazole

    go.drugbank.com/drugs/DB00257
    ApprovedInvestigationalVet approved

    This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. … As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094].

    Mixtures: SAEROGENTA-A CREAM, BAYCUTEN NCategories: P-glycoprotein inducers, P-glycoprotein inhibitors
  9. Indication

    Allergic purpura

    go.drugbank.com/conditions/DBCOND0102163
    Drugs: Chlorpheniramine
    Synonyms: Immunoglobulin A-associated vasculitis, Immunoglobulin A vasculitis (disorder)
  10. Drug

    Cimetidine

    go.drugbank.com/drugs/DB00501
    ApprovedInvestigational

    It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy. … A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions.

    Mixtures: Cimetidine 5% / Ibuprofen 2% / Salicylic Acid 17%, Cimetidine 10% / Lidocaine 5% / Salicylic Acid 40%Categories: MATE 1 Inhibitors, MATE 1 Substrates