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Displaying results 1761 - 1770 of 10000 in total
  1. Target

    Sodium- and chloride-dependent glycine transporter 1

    go.drugbank.com/bio_entities/BE0000940
    TransporterTargetHumans

    Sodium- and chloride-dependent glycine transporter (PubMed:37962965, PubMed:8183239). Essential for regulating glycine concentrations at inhibitory glycinergic synapses

    Polypeptides: Sodium- and chloride-dependent glycine transporter 1
  2. Target

    Troponin C, slow skeletal and cardiac muscles

    go.drugbank.com/bio_entities/BE0001024
    TargetHumans

    Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.

    Polypeptides: Troponin C, slow skeletal and cardiac muscles
  3. Target

    Sodium- and chloride-dependent glycine transporter 2

    go.drugbank.com/bio_entities/BE0002310
    TransporterTargetHumans

    Sodium- and chloride-dependent glycine transporter (PubMed:10381548, PubMed:10606742, PubMed:16751771, PubMed:31370103, PubMed:9845349).

    Polypeptides: Sodium- and chloride-dependent glycine transporter 2
  4. Target

    Signal transducer and activator of transcription 3

    go.drugbank.com/bio_entities/BE0003462
    TargetHumans

    Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity … Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR

    Polypeptides: Signal transducer and activator of transcription 3
  5. Target

    Disintegrin and metalloproteinase domain-containing protein 17

    go.drugbank.com/bio_entities/BE0003754
    TargetHumans

    Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). … Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:28923481)

    Polypeptides: Disintegrin and metalloproteinase domain-containing protein 17
  6. Target

    Macrophage scavenger receptor types I and II

    go.drugbank.com/bio_entities/BE0010942
    TargetHumans

    Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate … Recognizes and internalizes modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidized LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation

    Polypeptides: Macrophage scavenger receptor types I and IISynonyms: Macrophage acetylated LDL receptor I and II
  7. Target

    Cleavage and polyadenylation specificity factor subunit 3

    go.drugbank.com/bio_entities/BE0021153
    TargetHumans

    Has endonuclease activity, and functions as an mRNA 3'-end-processing endonuclease (PubMed:30507380). Also involved in the histone 3'-end pre-mRNA processing (PubMed:30507380). … Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.

    Polypeptides: Cleavage and polyadenylation specificity factor subunit 3Synonyms: Cleavage and polyadenylation specificity factor 73 kDa subunit
  8. Drug

    Dinoprostone

    go.drugbank.com/drugs/DB00917
    ApprovedInvestigational

    Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. … As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.

    Categories: Genito Urinary System and Sex HormonesProducts: Cervidil Controlled Release Vaginal Pessary 10mg
  9. Drug

    (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE

    go.drugbank.com/drugs/DB08186
    Experimental

    Synonyms: (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
  10. Drug

    Cefdinir

    go.drugbank.com/drugs/DB00535
    ApprovedInvestigational

    Cefdinir was approved by the FDA in 1997 to treat a variety of mild to moderate infections and was initially marketed by Abbvie. … It has been proven to be effective for the treatment of common bacterial infections in the ear, sinus, throat, lungs, and skin.

    International brands: Xi Fu NiProducts: ASEMAX 250MG/5ML ORAL SUSPANSIYON HAZIRLAMAK ICIN KURU TOZ, 100ML, MENACEF 250MG/5ML ORAL SÜSPANSIYON HAZIRLAMAK İÇİN KURU TOZ, (100 mL) 1 ŞIŞE