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Displaying results 1771 - 1780 of 10000 in total
  1. Target

    Lysophosphatidic acid receptor 1

    go.drugbank.com/bio_entities/BE0017535
    TargetHumans

    Receptor for lysophosphatidic acid (LPA) (PubMed:19306925, PubMed:25025571, PubMed:26091040, PubMed:9070858). … Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258).

    Polypeptides: Lysophosphatidic acid receptor 1Synonyms: LPA receptor 1, Lysophosphatidic acid receptor Edg-2
  2. Target

    Interleukin-17 receptor A

    go.drugbank.com/bio_entities/BE0018249
    TargetHumans

    Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). … Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848)

    Polypeptides: Interleukin-17 receptor ASynonyms: IL-17 receptor A
  3. Target

    Interleukin-17 receptor B

    go.drugbank.com/bio_entities/BE0020027
    TargetHumans

    Receptor for the pro-inflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells

    Polypeptides: Interleukin-17 receptor BSynonyms: IL-17 receptor B, IL-17B receptor
  4. Target

    Insulin receptor substrate 2

    go.drugbank.com/bio_entities/BE0021286
    TargetHumans

    Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670 … Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of

    Polypeptides: Insulin receptor substrate 2
  5. Drug

    Niclosamide

    go.drugbank.com/drugs/DB06803
    ApprovedInvestigationalVet approved

    They are an even greater problem in domestic animals. Niclosamide, once marketed in the US under the brand name Niclocide, was voluntarily withdrawn from market by Bayer in 1996.[L11860] … Niclosamide is an antihelminthic used for the treatment of tapeworm infections.

    Categories: Compounds used in a research, industrial, or household setting
  6. Drug

    Zinc sulfate, unspecified form

    go.drugbank.com/drugs/DB14548
    Approved

    Zinc sulfate is a common zinc supplement in parenteral nutrition.[A216916,L12888]

    Mixtures: Up and Up Ultra Itchy Relief, i-Drops ARTIFICIAL TEARS
  7. Drug

    Cholecystokinin

    go.drugbank.com/drugs/DB08862
    ApprovedInvestigationalWithdrawn

    Recent studies have suggested that cholecystokinin also plays a major role in inducing drug tolerance to opioids such as morphine and heroin, and is partially implicated in experiences of pain hypersensitivity … Normally, it is an endogenous hormone but is available commercially for diagnostic processes and replacement in pancreatic insufficiency [L1646, L1647, L1648]. in the octapeptide form.

  8. Drug

    Palbociclib

    go.drugbank.com/drugs/DB09073
    ApprovedInvestigational

    Palbociclib is a piperazine pyridopyrimidine[A176792] that acts in the cell cycle machinery. … It is a second generation cyclin-dependent kinase inhibitor[A176798] selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties.

  9. Drug

    Tipiracil

    go.drugbank.com/drugs/DB09343
    ApprovedInvestigational

    [A31255] TAS-102 is indicated for the treatment of metastatic colorectal cancer which has been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, or with an anti-VEGF … Tipiracil is a thymidine phosphorylase inhibitor. It is used in combination with trifluridine, in a ratio of 1:0.5, to form TAS-102.

  10. Drug

    Insulin pork

    go.drugbank.com/drugs/DB00071
    Approved

    Insulin isolated from pig pancreas. Composed of alpha and beta chains, processed from pro-insulin. Forms a hexameric structure.

    Categories: Drugs Used in Diabetes