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Encorafenib
go.drugbank.com/drugs/DB11718ApprovedInvestigational[L3344] On June 27, 2018, the Food and Drug Administration approved encorafenib and [binimetinib] (BRAFTOVI and MEKTOVI, Array BioPharma Inc.) in combination for patients with unresectable or metastatic … melanoma with a BRAF V600E or V600K mutation, as detected by an FDA-approved test.
Products: BRAFTOVI® 75 MG CÁPSULAS, BRAFTOVİ 75 MG SERT KAPSÜL, 42 ADETIsopropyl alcohol
go.drugbank.com/drugs/DB02325ApprovedInvestigationalAn isomer of 1-propanol. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
Synonyms: 2-PropanolMixtures: ChloraPrep 20 mg/ml + 0,7 ml/ml Lösung zur Anwendung auf der Haut, ChloraPrep gefärbt 20 mg/ml + 0,7 ml/ml Lösung zur Anwendung auf der HautPyrvinium
go.drugbank.com/drugs/DB06816ApprovedInvestigationalWithdrawnSeveral forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate. Pyrvinum's anti-cancer properties are currently under investigation.
Categories: Heterocyclic Compounds, 2-RingProducts: PIROK 50 ML SUSPANSIYON, PIROK SÜSPANSIYON, 25 MLFluocinolone acetonide
go.drugbank.com/drugs/DB00591ApprovedInvestigationalVet approvedFluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity. … [T357] It has been used extensively in dermatological preparations and it has also been investigated thoroughly for its use in implantable corticosteroid devices.
Mixtures: InfectoCiproCort 3 mg/ml + 0,25 mg/ml Ohrentropfen, Lösung, Fluocinolone Acetonide 0.025% / Lidocaine HCl Monohydrate 1%Products: FLUNOLONE-V CREAM 0.25 mg/g, ILUVIEN 190 Mikrogramm intravitreales Implantat im ApplikatorIsradipine
go.drugbank.com/drugs/DB00270ApprovedIt exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells
Categories: Heterocyclic Compounds, 1-RingProducts: DYNACIRC SRO 5 MG, DYNACIRC COMPRIMIDOS 2.5 MGDelamanid
go.drugbank.com/drugs/DB11637ApprovedInvestigationalMultidrug-resistant tuberculosis may also require more than 2 years of chemotherapy and second-line therapies with narrow therapeutic index [A31968]. … response to standardized antituberculosis treatments as [DB00951] and [DB01045].
Synonyms: (2R)-2-methyl-6-nitro-2-((4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)phenoxy)methyl)-2,3-dihydroimidazo(2,1-B)(1,3)oxazole, Imidazo(2,1-B)oxazole, 2,3-dihydro-2-methyl-6-nitro-2-((4-(4-(4-(trifluoromethoxy)phenoxy)-1-piperidinyl)phenoxy)methyl)-, (2R)-Categories: Heterocyclic Compounds, 1-RingClobetasol propionate
go.drugbank.com/drugs/DB01013ApprovedInvestigational[A190936] Clobetasol Propionate was granted FDA approval on 27 December 1985.[L11809] … [L11815] It has demonstrated superior activity compared to [fluocinonide][A190963] and was first described in the literature in 1974.
Synonyms: 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate, clobetasol 17-propanoateMixtures: Ciclopirox 1% / Clobetasol Propionate 0.05%, Clobetasol Propionate 0.05% / Levocetirizine Dihydrochloride 2%Apalutamide
go.drugbank.com/drugs/DB11901ApprovedInvestigationalApproximately 10 to 20 % of prostate cancer cases are castration-resistant, and up to 16% of these patients show no evidence of cancer metastasis at the time of castration-resistant diagnosis [L1295]. … In a phase-2 multicenter open-label study, 89% of patients with non-metastatic, castration-resistant prostate cancer had ≥50% PSA decline at week 12 of apalutamide treatment [A31846].
Categories: MATE 2 Inhibitors, MATE 1 InhibitorsProducts: ERLEADA ®TABLETAS RECUBIERTAS 60 MGCalcium ascorbate
go.drugbank.com/drugs/DB14483ApprovedNutraceuticalSynonyms: L-ascorbic acid, calcium salt (2:1)Mixtures: Chela-manganese 50 Plus, Energy 80 Prolonged Release TabCardiolipin Biosynthesis CL(10:0/20:0/20:0/i-20:0)
smpdb.ca/view/SMP0178977MetabolicCardiolipin (CL) is an important component of the inner mitochondrial membrane where it constitutes about 20% of the total lipid composition.