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Cyclobenzaprine Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126845Drug actionCyclobenzaprine is a centrally acting skeletal muscle relaxant structurally related to tricyclic antidepressants. Cyclobenzaprine relieves skeletal muscle spasms of local origin without interfering with muscle function. In preclinical re...
Enzymes: Sodium-dependent serotonin transporterClozapine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0125311Drug actionClozapine is an antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Clozapine is available as oral tablets. Clozapine is part of a group of drugs known as second-generation...
Enzymes: Sodium-dependent serotonin transporterPromazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126483Drug actionPromazine is used as an adjunct for short term treatment of moderate and severe psychomotor agitation. It is also used to treat agitation or restlessness in the elderly. Promazine is an antagonist at types 1, 2, and 4 dopamine receptors,...
Enzymes: Sodium-dependent dopamine transporterDroperidol Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126486Drug actionDroperidol is an organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2...
Enzymes: Sodium-dependent dopamine transporterFluspirilene Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126514Drug actionFluspirilene is an antipsychotic agent used in the treatment of schizophrenia. Fluspirilene is a relatively long-acting injectable depot antipsychotic drug used for schizophrenia. Fluspirilene does not differ greatly from other depot ant...
Enzymes: Sodium-dependent dopamine transporterFlupentixol Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126515Drug actionFlupentixol is a first generation antipsychotic drug of the thioxanthene group. It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. Flupentixol decanoate is one of the active ingredients found in i...
Enzymes: Sodium-dependent dopamine transporterFlupentixol Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126516Drug actionFlupentixol is a first generation antipsychotic drug of the thioxanthene group. It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. Flupentixol decanoate is one of the active ingredients found in i...
Enzymes: Sodium-dependent serotonin transporterPimozide Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126532Drug actionPimozide is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which one of the nitrogens is substituted by a piperidin-4-yl group, which in turn is substituted on the nitrogen by a 4,4-bis(p-fluoropheny...
Enzymes: Sodium-dependent dopamine transporterTrifluoperazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126561Drug actionTrifluoperazine is a trifluoro-methyl phenothiazine derivative. Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed ...
Enzymes: Sodium-dependent dopamine transporterMethotrimeprazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126562Drug actionMethotrimeprazine is a phenothiazine derivative, a first-generation antipsychotic, dopamine receptor antagonists (DRA) and a typical antipsychotic. Methotrimeprazine's antipsychotic effect is largely due to its antagonism of dopamine rec...
Enzymes: Sodium-dependent dopamine transporter