Search
Calaspargase pegol
go.drugbank.com/drugs/DB14730ApprovedInvestigationalAsparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. … This forms the basis of asparaginase treatment in ALL [A40270], [A40273], [F2432].
Categories: Compounds used in a research, industrial, or household setting, L-asparaginase containing drugsRamucirumab
go.drugbank.com/drugs/DB05578ApprovedInvestigationalIn contrast to other agents directed against VEGFR-2, ramucirumab binds a specific epitope on the extracellular domain of VEGFR-2, thereby blocking all VEGF ligands from binding to it. … VEGFR stimulation also mediates downstream signalling required for angiogenesis and is postulated to be heavily involved in cancer progression, making it a highly likely drug target.
Categories: Vascular Endothelial Growth Factor Receptor 2 AntagonistProducts: CYRAMZA®, CYRAMZA 100MG/10 ML INFÜZYONLUK ÇÖZELTI KONSANTRESI IÇEREN FLAKON, 1 ADETSimeprevir
go.drugbank.com/drugs/DB06290ApprovedWithdrawnor second-line threapies for treatment-naïve patients as adjunct to sofosbuvir treatment for genotype 1 or PEG-Interferon/ribavirin combination therapy for genotype 1 or 4. … According to 2017 American Association for the Study of Liver Diseases (AASLD) and 2015 consensus guidelines from the Canadian Association for the Study of the Liver (CASL), simeprevir can be used as first-line
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsTechnetium Tc-99m tetrofosmin
go.drugbank.com/drugs/DB09160ApprovedTechnetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging. … It is a lipophilic technetium phosphine dioxo cation that was formulated into a freeze-dried kit which yields an injection.
Categories: Compounds used in a research, industrial, or household setting, P-glycoprotein substratesAcarbose
go.drugbank.com/drugs/DB00284ApprovedInvestigationalAcarbose is therefore used in conjunction with diet, exercise, and other pharmacotherapies for the management of blood sugar levels in patients with type 2 diabetes. … Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines.
Categories: Drugs Used in DiabetesProducts: GLUCOBAY® 50MG TABLETAS, GLUCOBAY® 100MG TABLETASMifamurtide
go.drugbank.com/drugs/DB13615ApprovedInvestigationalWhile about 90% of patients with newly diagnosed osteosarcoma may achieve complete remission from first-line therapies, the prognosis is still poor for patients with non-metastatic osteosarcoma with lower … Also called L-MTP-PE, mifamurtide may be a liposomal form of of the active ingredient MTP-PE, which is a synthetic, less pyrogenic, and longer-acting derivative of muramyl dipeptide (MDP).
Products: MEPACT 4 MG INFÜZYONLUK DISPERSIYON KONSANTRESI IÇIN TOZ ,FLAKON, 1 ADET, MEPACT® POLVO PARA CONCENTRADO PARA DISPERSIÓN PARA PERFUSIÓNFinasteride
go.drugbank.com/drugs/DB01216ApprovedInvestigationalIt works in a similar fashion as [dutasteride], which is another 5-alpha-reductase inhibitor, by exerting antiandrogenic effects. … [L6244] Finasteride is commonly marketed under the brand names Propecia and Proscar to be used aloneo or in combination with [doxazosin], an alpha-blocker.
Mixtures: Finasteride 0.1% / Minoxidil 7%, Finasteride 0.1% / Minoxidil 5%Categories: Drugs Used in Benign Prostatic Hypertrophy, 5-alpha Reductase InhibitorsThimerosal
go.drugbank.com/drugs/DB11590ApprovedAlthough thimerosal is banned in several countries, it continues to be included as a preservative in some vaccines in the United States and many vaccines in the developing world [L1685]. … Thiomersal (INN), commonly known in the U.S. as thimerosal, is an organomercury compound. This compound is a well-established and widely used antiseptic and antifungal agent.
Categories: Compounds used in a research, industrial, or household settingSynonyms: ethyl(2-mercaptobenzoato-S)mercury sodium salt, [(o-carboxyphenyl)thio]ethylmercury sodium saltPotassium bicarbonate
go.drugbank.com/drugs/DB11098ApprovedInvestigationalIt is used in medicine as an antacid.[T141] It is registered in the FDA under the section of suitable, safe and effective ingredients for OTC antacids. … Potassium bicarbonate is a white, crystalline, slightly alkaline and salty substance. It is produced by the passage of carbon dioxide through an aqueous potassium carbonate solution.
Mixtures: Multi-min Electro C Pow Plus B2, POT-K 1,56 G EFERVESAN TABLET, 60 ADETProducts: Klor-con/ef, KLOR-Con/EFJoubert Syndrome
smpdb.ca/view/SMP0000582DiseaseThe symptoms affect a variety of body parts in the patient, including apnea, ataxia brought on by hypotonia, abnormal eye movements and intellectual disability. … Joubert syndrome is a condition in which brain development is not completed as it should be, including the lack or underdevelopment of the part of the brain that regulates balance and coordination and
Enzymes: Activating molecule in BECN1-regulated autophagy protein 1