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Displaying results 1861 - 1870 of 3599 in total
  1. Drug

    N-Acetylmethionine

    go.drugbank.com/drugs/DB01646
    Investigational

    Mixtures: AZONEFROL-PD PERİTON DİYALİZ ÇÖZELTİSİ, 2000 ML TEKLİ TORBA, AZONEFROL-PD PERİTON DİYALİZ ÇÖZELTİSİ, 2500 ML ÇİFTLİ TORBA
  2. Drug

    Ipilimumab

    go.drugbank.com/drugs/DB06186
    ApprovedInvestigational

    Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes. Ipilimumab was developed by Bristol...

  3. Target

    Solute carrier family 52, riboflavin transporter, member 2

    go.drugbank.com/bio_entities/BE0004841
    TargetTransporterHumans

    May also act as a receptor for 4-hydroxybutyrate (Probable)

    Synonyms: PERV-A receptor 1, Porcine endogenous retrovirus A receptor 1Function: 4-hydroxybutyrate receptor activity
  4. Target

    P2Y purinoceptor 12

    go.drugbank.com/bio_entities/BE0000110
    TargetHumans

    Receptor for ADP and ATP coupled to G proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation

    Synonyms: ADP-glucose receptor, P2Y12 platelet ADP receptorFunction: G protein-coupled adenosine receptor activity
  5. Target

    Growth arrest-specific protein 6

    go.drugbank.com/bio_entities/BE0010201
    TargetHumans

    Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell su...

    Synonyms: AXL receptor tyrosine kinase ligand
  6. Drug

    VPM1002

    go.drugbank.com/drugs/DB15801
    Investigational

    By reducing urease C, phagosome acidification can occur, promoting phagolysosome fusion while also providing the optimal low pH for listeriolysin O stability. … Because Hly is only active at an acidic pH, similar to listeriolysin O, the deletion of urease C was also beneficial for Hly to have optimal bioactivity in the phagosome.

  7. Drug

    Amrubicin

    go.drugbank.com/drugs/DB06263
    Investigational

    Amrubicin is a third-generation synthetic anthracycline currently in development for the treatment of small cell lung cancer. Pharmion licensed the rights to Amrubicin in November 2006. In 2002, Amrubicin was approved and launched for sa...

  8. Target

    T-cell surface glycoprotein CD3

    go.drugbank.com/bio_entities/BE0010202
    TargetHumans

    In addition to its role as a TCR coreceptor, it serves as a receptor for ITPRIPL1 (PubMed:38614099). … Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G

    Synonyms: T-cell receptor T3 delta chain, T-cell receptor T3 zeta chain
  9. Drug

    Nabilone

    go.drugbank.com/drugs/DB00486
    ApprovedInvestigational

    It is also approved for use in treatment of anorexia and weight loss in patients with AIDS. Nabilone is a racemate consisting of the (S,S) and the (R,R) isomers. … While both CBD and THC are used for medicinal purposes, they have different receptor activity, function, and physiological effects.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Inhibitors
  10. Target

    Beta-galactosidase

    go.drugbank.com/bio_entities/BE0009999
    TargetEnzymeHumans

    Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans

    Synonyms: Elastin receptor 1