Search
Eukaryotic elongation factor 2 kinase
go.drugbank.com/bio_entities/BE0011325TargetHumansUpon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive.
Synonyms: Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinaseProtein S100-A1
go.drugbank.com/bio_entities/BE0001090TargetHumansIn response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). … Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600).
Synonyms: S100 calcium-binding protein A1Sulfite reductase [NADPH] flavoprotein alpha-component
go.drugbank.com/bio_entities/BE0002963TargetEscherichia coli (strain K12)Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
Polypeptides: Sulfite reductase [NADPH] flavoprotein alpha-componentSulfite reductase [NADPH] hemoprotein beta-component
go.drugbank.com/bio_entities/BE0001900TargetEscherichia coli (strain K12)Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
Polypeptides: Sulfite reductase [NADPH] hemoprotein beta-componentProtein S100-A11
go.drugbank.com/bio_entities/BE0002789TargetHumansFacilitates the differentiation and the cornification of keratinocytes
Synonyms: S100 calcium-binding protein A11Merozoite surface protein 1
go.drugbank.com/bio_entities/BE0009218TargetPlasmodium falciparum (isolate CDC / Honduras)Involved in the binding to host erythrocytes and is required for host erythrocyte invasion (By similarity). … asexual blood stage, involved in merozoite egress from host erythrocytes possibly via its interaction with the host cytoskeleton protein spectrin resulting in the destabilization of the host cytoskeleton and
Polypeptides: Merozoite surface protein 1Synonyms: Merozoite surface antigen, Merozoite surface antigensLeukocyte surface antigen CD47
go.drugbank.com/bio_entities/BE0010649TargetHumansPlays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). … Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764).
Polypeptides: Leukocyte surface antigen CD47Synonyms: Antigenic surface determinant protein OA3Ryanodine receptor 2
go.drugbank.com/bio_entities/BE0005295TargetTransporterHumansCytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. … In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C.
Synonyms: Cardiac muscle ryanodine receptor-calcium release channelFunction: calcium channel activityProtein S100-A12
go.drugbank.com/bio_entities/BE0001206TargetHumansS100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. … Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus
Synonyms: S100 calcium-binding protein A12, Calcium-binding protein in amniotic fluid 1Function: calcium ion bindingCell surface A33 antigen
go.drugbank.com/bio_entities/BE0010757TargetHumansMay play a role in cell-cell recognition and signaling
Polypeptides: Cell surface A33 antigen