Search
AV608
go.drugbank.com/drugs/DB05072InvestigationalAV608 is a NK-1 antagonist. It is developed for the treatment of Social anxiety disorder (SAD), irritable bowel syndrome (IBS) and overactive bladder (OAB).
Activated CDC42 kinase 1
go.drugbank.com/bio_entities/BE0000772TargetHumansContributes to the control of AXL receptor levels. … Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin.
Synonyms: Tyrosine kinase non-receptor protein 2Integrin alpha-M
go.drugbank.com/bio_entities/BE0010412TargetHumansIt is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. … Integrin ITGAM/ITGB2 is also a receptor for ICAM1 ligand ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124).
Synonyms: Neutrophil adherence receptor, Leukocyte adhesion receptor MO1High affinity cationic amino acid transporter 1
go.drugbank.com/bio_entities/BE0000212TargetTransporterHumansHigh-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues
Synonyms: Ecotropic retrovirus receptor homolog, Ecotropic retroviral leukemia receptor homologHepatocyte nuclear factor 4-gamma
go.drugbank.com/bio_entities/BE0003179TargetHumansTranscription factor. Has a lower transcription activation potential than HNF4-alpha
Synonyms: Nuclear receptor subfamily 2 group A member 2Mediator of RNA polymerase II transcription subunit 1
go.drugbank.com/bio_entities/BE0004382TargetHumansComponent of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the ...
Synonyms: Thyroid receptor-interacting protein 2, Peroxisome proliferator-activated receptor-binding proteinLenacapavir
go.drugbank.com/drugs/DB15673ApprovedInvestigationalHIV/AIDS remains an area of concern despite the introduction of numerous successful therapies, mainly due to the emergence of multidrug resistance and patient difficulty in adhering to treatment regimens. Lenacapavir is a first-in-class ...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesBupropion
go.drugbank.com/drugs/DB01156ApprovedInvestigational[L6562,A179038,A179050] The combination of naltrexone and bupropion was shown to result in a statistically significant weight loss, with a mean change in body weight of -6.3% compared to -1.3% for placebo … [L6562] Studies have shown that the combined activity of bupropion and [naltrexone] increase the firing rate of hypothalamic pro-opiomelanocortin (POMC) neurons and blockade of opioid receptor-mediated
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesNeutral amino acid transporter B(0)
go.drugbank.com/bio_entities/BE0000236TargetTransporterHumansMediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons.
Synonyms: Baboon M7 virus receptor, RD114/simian type D retrovirus receptorDeoxyhypusine hydroxylase
go.drugbank.com/bio_entities/BE0018877TargetHumansCatalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-tran...
Synonyms: HEAT-like repeat-containing protein 1