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Etrolizumab
go.drugbank.com/drugs/DB12189Investigational[A244564, A244569, A244579, A244584] A recent class of drugs designed to impair lymphocyte homing, so-called "anti-trafficking agents" (ATAs), have shown some success and include approved drugs such as … [A244564, A244584] Etrolizumab is a humanized IgG1κ monoclonal antibody directed against the β7 subunit of gastrointestinal α4β7 and αEβ7 integrins that, due to its target specificity, appears as or more
Categories: Integrin Receptor AntagonistAcrivastine
go.drugbank.com/drugs/DB09488ApprovedAs an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension … Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever.
Pholcodine
go.drugbank.com/drugs/DB09209ApprovedIllicitPholcodine formula is 3-o-morpholinoethylmorphine and it is classified as an antitussive which is defined as an opioid cough suppressant. … [A31742] Pholcodine is not prescribed in the United States where it is classed as a Schedule I drug. It is categorized as Class B drug in the UK and officially taken out of the shelves in 2008.
Pheniramine
go.drugbank.com/drugs/DB01620ApprovedPheniramine's use as an anti-allergy medication has largely been supplanted by second-generation antihistamines such as [cetirizine] and [loratadine]. … [A181628] It is used in some over-the-counter allergy as well as cold & flu products in combination with other drugs.
Mixtures: Opcon-A, Opcon-AD-alpha-Tocopherol acetate
go.drugbank.com/drugs/DB14002ApprovedNutraceuticalVet approvedMoreover, RRR-alpha-tocopherol acetate is a relatively stabilized form of vitamin E that is most commonly used as a food additive when needed [A32451]. … At the moment however, there exists a lack of formal data and evidence to support any such additional indications for vitamin E use.
Mixtures: Vitamin A C E W.niacinam.beta Car.and Min., Coen.q10w.vit.c and E Beta-car.se Cu Zn MnCategories: Compounds used in a research, industrial, or household settingGanaxolone
go.drugbank.com/drugs/DB05087ApprovedInvestigationalGanaxolone is the 3β-methylated synthetic analog of [allopregnanolone],[L41130] a metabolite of [progesterone].[A3197] Ganaxolone belongs to a class of compounds referred to as neurosteroids. … [A245995] Ganaxolone, similar to its endogenous counterparts, is a positive allosteric modulator of GABA<sub>A</sub> receptors.
Categories: Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive ModulatorAlprostadil
go.drugbank.com/drugs/DB00770ApprovedInvestigationalAlprostadil is a chemically-identical synthetic form of prostaglandin E1 (PGE1), a potent vasodilator produced endogenously. … In 1996, the FDA approved the use of alprostadil, administered either with an intracavernosal injection or an intraurethral suppository, for the treatment of erectile dysfunction, and it is used in men
Categories: Prostaglandin Receptor AgonistsPotassium
go.drugbank.com/drugs/DB14500ApprovedInvestigationalPotassium is an essential nutrient, like [Calcium] and [Magnesium]. It was identified as a shortfall nutrient by the 2015-2020 Advisory Committee of Dietary Guidelines for Americans. … Hypokalemia (low potassium) or hyperkalemia (high potassium) may result, manifesting as various signs and symptoms.
Mixtures: One A Day Tab, Extra Once A DayProducts: Port A Mins Super Potassium 99Uric acid
go.drugbank.com/drugs/DB08844InvestigationalAs a therapeutic agent, it is known that uric acid is increased in response to oxidative stress, and as such, uric acid acts as an antioxidant. … In one country, Spain, uric acid is an investigational drug in a phase 3 trial studying its effects as an adjunct to alteplase in acute ischemic stroke.
Categories: Compounds used in a research, industrial, or household settingNorgestimate
go.drugbank.com/drugs/DB00957ApprovedInvestigational[A191068] It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects. … [A191068] It is commonly formulated with [ethinylestradiol] as a combined oral contraceptive that can also be used to treat moderate acne vulgaris.