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Mitochondrial peptide methionine sulfoxide reductase
go.drugbank.com/bio_entities/BE0000170TargetEnzymeHumansPlays a crucial role in repairing oxidized methionine residues in key lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS), thereby restoring their function and maintaining lens … Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Synonyms: Peptide Met(O) reductaseThioproperazine
go.drugbank.com/drugs/DB01622ApprovedIt is used for the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics; manic syndromes. … It is virtually without antiserotonin and hypotensive action and has no antihistaminic property.
Synonyms: N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine-2-sulfonamide, N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine-2-sulfonamideCategories: Dopamine D2 Receptor Antagonists, Heterocyclic Compounds, 3-RingPeptide methionine sulfoxide reductase MsrA
go.drugbank.com/bio_entities/BE0001618TargetShigella flexneriCatalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
Synonyms: Peptide Met(O) reductaseLinagliptin
go.drugbank.com/drugs/DB08882ApprovedInvestigationalLinagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding[A37050 … Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes [L9557].
Synonyms: (R)-8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dioneMixtures: GLYXAMBI® 25 MG/ 5 MG, GLYXAMBI® 10 MG/ 5 MGOsteoarthritis (OA)
go.drugbank.com/conditions/DBCOND0056529Drugs: Aceclofenac · Acetaminophen · Benzyl nicotinate · Bupivacaine · Capsaicin · Celecoxib +36 moreSynonyms: O/AEntecavir
go.drugbank.com/drugs/DB00442ApprovedInvestigationalIt was approved by the U.S. Food and Drug Administration (FDA) in March 2005. … Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS).
Categories: Hepatitis B virus, Cytochrome P-450 SubstratesProducts: ENTECAVIR DR. REDDY'S, KALVIR® 1 MGDeferiprone
go.drugbank.com/drugs/DB08826ApprovedInvestigationalDeferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. … Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired.
Synonyms: 1,2-Dimethyl-3-hydroxypyrid-4-one, 3-Hydroxy-1,2-dimethyl-4(1H)-pyridoneCategories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 SubstratesJuvenile Cataracts
go.drugbank.com/conditions/DBCOND0135843Drugs: BendazacSynonyms: Cataract in ChildScaling of skin
go.drugbank.com/conditions/DBCOND0097701Drugs: Salicylic acidSynonyms: Changes in skin textureCamizestrant
go.drugbank.com/drugs/DB19218ApprovedInvestigational[L64117,L64107,L64116] It is the first next-generation oral SERD and complete ER antagonist approved in the first-line setting, and the only one approved for use with all three widely approved CDK4/6 inhibitors … [L64094,L64107] Patients are selected for treatment on the basis of an *ESR1* mutation detected by circulating tumor DNA testing during first-line endocrine therapy, before radiographic disease progression
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: 3-pyridinamine, n-(1-(3-fluoropropyl)-3-azetidinyl)-6-((6s,8r)-6,7,8,9-tetrahydro-8-methyl-7-(2,2,2-trifluoroethyl)-3h-pyrazolo(4,3-f)isoquinolin-6-yl)-, N-(1-(3-fluoropropyl)-3-azetidinyl)-6-((6s,8r)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3h-pyrazolo(4,3-f)isoquinolin-6-yl)-3-pyridinamine