Search

Displaying results 11 - 20 of 4672 in total
  1. Pathway

    Calcium undecylenate Drug Metabolism

    smpdb.ca/view/SMP0130615
    Metabolic

    Calcium undecylenate passes through the liver and is then excreted from the body mainly through the kidney. … Calcium undecylenate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Calcium undecylenate
  2. Pathway

    Verapamil Calcium Channel Vasodilation Action Pathway

    smpdb.ca/view/SMP0126373
    Drug action

    The inhibition of L-type calcium channels prevents the influx of calcium in vascular smooth muscle myocytes and the heart's cardiomyocytes, which prevents contraction of vascular smooth muscles and heart … Verapamil is an L-type calcium channel blocker with antiarrhythmic, antianginal, and antihypertensive activity.

    Drugs: ATP · Verapamil · Calcium · Magnesium cation
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent calcium channel subunit alpha-2/delta-1
  3. Pathway

    Calcium Gluceptate Drug Metabolism Pathway

    smpdb.ca/view/SMP0145439
    Metabolic

    Gadoversetamide is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Gadoversetamide passes through the liver and is then excreted from the body mainly through the kidney.

    Drugs: Calcium glucoheptonate
  4. Pathway

    Diltiazem Calcium Channel Vasodilation Action Pathway

    smpdb.ca/view/SMP0126505
    Drug action

    This effect is thought to be mediated by the voltage-dependent block of the L-type calcium channels and inhibition of calcium ion release from the ER stores, without altering the sodium-calcium coupled … transport or calcium sensitivity of myofilaments.

    Drugs: ATP · Diltiazem · Calcium · Magnesium cation
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent calcium channel subunit alpha-2/delta-1
  5. Pathway

    Edetate calcium disodium anhydrous Drug Metabolism

    smpdb.ca/view/SMP0130583
    Metabolic

    Edetate calcium disodium anhydrous passes through the liver and is then excreted from the body mainly through the kidney. … Edetate calcium disodium anhydrous is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Edetate calcium disodium anhydrous
  6. Pathway

    Cinnarizine Calcium Channel Vasodilation Action Pathway

    smpdb.ca/view/SMP0126667
    Drug action

    Cinnarizine is an antihistamine and a calcium channel blocker. Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels. … Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain.

    Drugs: ATP · Cinnarizine · Calcium · Magnesium cation
    Enzymes: Voltage-dependent T-type calcium channel subunit alpha-1G, Voltage-dependent T-type calcium channel subunit alpha-1H
  7. Pathway

    Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126292
    Drug action

    This effect is thought to be mediated by the voltage-dependent block of the L-type calcium channels and inhibition of calcium ion release from the ER stores, without altering the sodium-calcium coupled … transport or calcium sensitivity of myofilaments.

    Drugs: Diltiazem · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent T-type calcium channel subunit alpha-1G
  8. Pathway

    Flunarizine Calcium Channel Artery Dilation Action Pathway

    smpdb.ca/view/SMP0126303
    Drug action

    Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. … Flunarizine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel.

    Drugs: ATP · Calcium · Magnesium cation · Flunarizine
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent calcium channel subunit alpha-2/delta-1
  9. Pathway

    Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126428
    Drug action

    This activity is dependent on calcium influx through L-type calcium channels. … Activation of L-type calcium channels allows the influx of calcium ions into the muscles upon depolarization and excitation of the channel.

    Drugs: Verapamil · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent T-type calcium channel subunit alpha-1G
  10. Pathway

    Enflurane Calcium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126668
    Drug action

    My decreasing the amount of intracellular calcium available, calcium cannot readily bind to calmodulin and muscle contraction is inhibited. … Studies have found that enflurane binds to the calcium channels in the cardiac sarcoplasmic reticulum causing cardio depressant effects.

    Drugs: ATP · Enflurane · Epinephrine · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G