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Displaying results 11 - 20 of 32 in total
  1. Drug

    Paclitaxel

    go.drugbank.com/drugs/DB01229
    ApprovedInvestigationalVet approved

    Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree whi...

  2. Drug

    Thiocolchicoside

    go.drugbank.com/drugs/DB11582
    Investigational

    Thiocolchicoside is a semi-synthetic derivative of the colchicine, a natural anti-inflammatory glycoside which originates from the flower seeds of _Superba gloriosa_.

  3. Indication

    Pericarditis

    go.drugbank.com/conditions/DBCOND0007278
    Drugs: Acetylsalicylic acid · Azathioprine · Benzylpenicillin · Colchicine · Diclofenac · Ibuprofen +3 more
  4. Drug

    Tirbanibulin

    go.drugbank.com/drugs/DB06137
    ApprovedInvestigational

    Tirbanibulin (KX-O1 or KX2–391) is a dual inhibitor of Src Kinase and tubulin. On December 14, 2020, tirbanibulin was approved by the FDA for the topical treatment of actinic keratosis on the face or scalp. It is marketed under the brand...

  5. Drug

    ZEN-012

    go.drugbank.com/drugs/DB06042
    Experimental

    ZEN-012 is a novel small molecule and the first anti-cancer drug in development involving two mechanisms of action: tubulin and topoisomerase II inhibition. ZEN-012 also expresses additional modes of action such as pro-apoptotic and anti...

  6. Drug

    Oxibendazole

    go.drugbank.com/drugs/DB04910
    ExperimentalVet approved

    Oxibendazole is a polymerase inhibitor in phase III trials for the treatment of helminth intestinal infections.

  7. Drug

    Canakinumab

    go.drugbank.com/drugs/DB06168
    ApprovedInvestigational

    Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-r...

  8. Drug

    RGN6024

    go.drugbank.com/drugs/DB33059
    Experimental

    Preclinical characterization reports that RGN6024 binds the colchicine-binding site of beta-tubulin, inhibits microtubule polymerization in biochemical and cellular assays, induces G2/M arrest in glioblastoma

  9. Drug

    Opium

    go.drugbank.com/drugs/DB11130
    ApprovedIllicit

    Some of the isolated derivatives of opium are morphine, noscapine, strychnine, veratrine, colchicine, codeine, and quinine.

  10. Indication

    Cardiovascular Mortality

    go.drugbank.com/conditions/DBCOND0040959
    Drugs: Acetylsalicylic acid · Canagliflozin · Colchicine · Dapagliflozin · Empagliflozin · Evolocumab +12 more