Cardiovascular Mortality (DBCOND0040959)

Identifiers

Synonyms

Death, Cardiac / Cardiac Death / Cardiovascular Death

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetylsalicylic acid	A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Aldo-keto reductase family 1 member C1target Solute carrier family 22 member 6transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme 5'-AMP-activated protein kinasetarget Endothelin-1 receptortarget Cellular tumor antigen p53target Endoplasmic reticulum chaperone BiPtarget Ribosomal protein S6 kinase alpha-3target NF-kappa-B inhibitor alphatarget Tumor necrosis factor-inducible gene 6 proteintarget Caspase-1target Caspase-3target Inhibitor of nuclear factor kappa-B kinase subunit betatarget Extracellular signal-regulated kinase (ERK)target G1/S-specific cyclin-D1target Myc proto-oncogene proteintarget Proliferating cell nuclear antigentarget Cyclin Atarget UDP-glucuronosyltransferase 1-6enzyme Arylamine N-acetyltransferase 2enzyme Organic anion transporter 3transporter Sialidase-1target 3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
Canagliflozin	A sodium-glucose co-transporter 2 (SGLT2) inhibitor used to manage hyperglycemia in type 2 diabetes mellitus (DM). Also used to reduce the risk of major cardiovascular events in patients with established cardiovascular disease and type 2 DM.	UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B4enzyme Cytochrome P450 3A4enzyme Sodium/glucose cotransporter 2target ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Alpha-1-acid glycoprotein 1carrier Broad substrate specificity ATP-binding cassette transporter ABCG2transporter
Colchicine	An alkaloid used to treat gout and Familial Mediterranean Fever as well as prevent major cardiovascular events.	Tubulin beta chaintarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2E1enzyme Albumincarrier
Dapagliflozin	A sodium-glucose cotransporter 2 inhibitor used in the management of type 2 diabetes mellitus.	Sodium/glucose cotransporter 2target Cytochrome P450 1A1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B4enzyme UDP-glucuronosyltransferase 2B7enzyme ATP-dependent translocase ABCB1transporter
Empagliflozin	An SGLT2 inhibitor used to manage type 2 diabetes mellitus.	Sodium/glucose cotransporter 2target UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 1A8enzyme UDP-glucuronosyltransferase 1A9enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter
Finerenone	A nonsteroidal mineralocorticoid receptor antagonist indicated to lower the risk of eGFR decline, end stage kidney disease, cardiovascular death, heart attack, and hospitalization for heart failure in chronic kidney disease associated with type 2 diabetes.	Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Albumincarrier Mineralocorticoid receptortarget Cytochrome P450 1A1enzyme
Metformin	A biguanide antihyperglycemic used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus. It is also used off-label for insulin resistance in polycystic ovary syndrome (PCOS).	5'-AMP-activated protein kinase subunit beta-1target Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Multidrug and toxin extrusion protein 1transporter Equilibrative nucleoside transporter 4transporter Solute carrier family 22 member 3transporter Multidrug and toxin extrusion protein 2transporter Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialtarget Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmictarget Acetyl-CoA carboxylase 2target Multidrug and toxin extrusion protein 1target
Propranolol	A non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma.	Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Beta-3 adrenergic receptortarget 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 1Btarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Alpha-1-acid glycoprotein 1carrier Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Amine oxidase [flavin-containing] Aenzyme Albumincarrier
Reteplase	A purified form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli.	Fibrinogen alpha chaintarget Plasminogentarget Plasminogen activator inhibitor 1target
Rivaroxaban	A factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations.	Coagulation factor Xtarget Cytochrome P450 3A4enzyme Cytochrome P450 2J2enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 3A5enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter
Sacubitril	A neprilysin inhibitor used in combination with valsartan as an adjunct to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.	Neprilysintarget Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter
Sotagliflozin	An orally administered dual SGLT1/2 inhibitor used alongside insulin to improve glycemic control in patients with type 1 diabetes mellitus.	UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 3A4enzyme Sodium/glucose cotransporter 2target Sodium/glucose cotransporter 1target Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter ATP-binding cassette sub-family C member 2transporter
Tenecteplase	A modified form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli.	Urokinase plasminogen activator surface receptortarget Plasminogen activator inhibitor 1target Fibrinogen alpha chaintarget Plasminogen activator inhibitor 2target Tetranectintarget Keratin, type II cytoskeletal 8target Annexin A2target Calreticulintarget Calnexintarget Prolow-density lipoprotein receptor-related protein 1target Plasminogentarget
Ticagrelor	A P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death.	Cytochrome P450 3A4enzyme P2Y purinoceptor 12target ATP-dependent translocase ABCB1transporter Cytochrome P450 2C9enzyme Albumincarrier Cytochrome P450 3A5enzyme Cytochrome P450 2B6enzyme
Valsartan	An angiotensin-receptor blocker used to manage hypertension alone or in combination with other antihypertensive agents and to manage heart failure in patients who are intolerant to ACE inhibitors.	Type-1 angiotensin II receptortarget Cytochrome P450 2C9enzyme Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1B1transporter ATP-binding cassette sub-family C member 2transporter
Vericiguat	A soluble guanylate cyclase stimulator used to reduce heart failure-related hospitalization and cardiovascular death in patients with chronic systolic heart failure.	UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 1A1enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Albumincarrier Guanylate cyclase soluble subunit beta-1target Retinal guanylyl cyclase 1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03272854	TransplantLines Insulin Resistance and Inflammation Biobank and Cohort Study	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT05296694	Mortality Predictors in Coronary Care in Turkey	No drug interventions	Not Available	Not Available	completed
NCT05115994	Antihypertensive and PAP Treatment in Obstructive Sleep Apnea Patients With Hypertension (AHPAP)	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT04077294	Preoperative BNP: Epidemiological Patterns, Management Strategies and Cost Analysis of Care	No drug interventions	Not Available	Not Available	completed
NCT05189847	Clinical Register Studying the therApeutic Patient Population With Multifocal Atherosclerosis	No drug interventions	Not Available	Not Available	completed
NCT01682096	Pilot Safety Study of Coronary CTA for the Diagnosis of Acute Coronary Syndrome in the Emergency Room	No drug interventions	diagnostic	Not Available	completed
NCT05654935	Telerobotic Ultrasound for Carotid Imaging - Feasibility Study	No drug interventions	Not Available	Not Available	withdrawn
NCT01340963	The Signal-averaged ElectrocArdiogram in Long Term Follow-up of Chronic CHagas Disease - RIO de Janeiro Cohort	No drug interventions	Not Available	Not Available	completed
NCT02446730	Efficacy and Safety of BiomatrixTM Stent and 5mg-Maintenance Dose of Prasugrel in Patients With Acute Coronary Syndrome	Clopidogrel	treatment	4	unknown_status
NCT03892265	A Longitudinal Cohort Study to Evaluate Cardiovascular Risk Factors and Disease in Haiti	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT01594073	Evaluation of Novel Biomarkers to Improve Risk Stratification and Patient Selection in Implantable Cardioverter-defibrillator (ICD) Therapy	No drug interventions	Not Available	Not Available	completed
NCT03769740	Cerebral Oximetry and NIRS in Cardiac Arrest Patients	No drug interventions	Not Available	Not Available	unknown_status
NCT05778981	Endothelial Dysfunction and Non-cardiac Surgery	No drug interventions	Not Available	Not Available	recruiting
NCT03118895	Leaders Free III: BioFreedom™ Clinical Trial	No drug interventions	treatment	Not Available	completed
NCT02298543	Coronary Spasm Presenting Aborted Sudden Cardiac Death, the Multicenter Registry	No drug interventions	Not Available	Not Available	completed
NCT02097602	Correlation Between Reticulated Platelets and Major Adverse Cardiac and Cerebrovascular Events After Noncardiac Surgery	No drug interventions	Not Available	Not Available	completed
NCT01217528	Reduction of Inappropriate Implantable Cardioverter Defibrillator (ICD) Therapies in Primary Prevention Patients	No drug interventions	treatment	Not Available	completed
NCT03393793	HEart trAnsplantation Registry of piTie-Salpetriere University Hospital	No drug interventions	Not Available	Not Available	completed
NCT04657393	Ventilation in Cardiac Arrest	No drug interventions	treatment	Not Available	terminated
NCT02060071	Endothelial Progenitors in Aortic Stenosis: Association With Aortic Stenosis Progression and Severity	No drug interventions	health_services_research	4	unknown_status
NCT03307213	BioFreedom QCA Study in CAD Patients	No drug interventions	treatment	Not Available	unknown_status
NCT00825773	A Study to Evaluate Safety and Efficacy of the ExcelTM Sirolimus Eluting Stent With a Biodegradable Polymer Versus Sirolimus Eluting Stent With Non-Biodegradable Polymer in the Treatment of Patients With de Novo Coronary Artery Lesions	No drug interventions	treatment	4	unknown_status
NCT04295291	Quality of Cardiopulmonary Resuscitation Pre- and Intra Hospital	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT04580992	Defining the Electrocardiographic Effect of Propofol on the Ajmaline Provocation Drug Challenge: A Prospective Trial	Ajmaline	Not Available	Not Available	unknown_status
NCT04547244	CRTd Responders Optimization	No drug interventions	Not Available	Not Available	completed
NCT04548804	Better Mechanistic Understanding of and Risk Stratification for Ventricular Tachyarrhythmias Through ECGI	No drug interventions	basic_science	Not Available	enrolling_by_invitation
NCT01252823	Implantable Loop Recorder in Hemodialysis Patients	No drug interventions	prevention	Not Available	completed
NCT03154203	Non-Invasive Aortic Ambulatory Blood Pressure Monitoring for The Detection of Target Organ Damage in The Chinese Population	No drug interventions	Not Available	Not Available	unknown_status
NCT02425345	Women's Health Initiative Strong and Healthy Study	No drug interventions	prevention	Not Available	active_not_recruiting
NCT00710788	Reduce Cardiovascular Calcifications to Reduce QT Interval in Dialysis	Calcium carbonate Sevelamer	treatment	Not Available	completed
NCT00973206	Factors Influencing Cardiovascular Prognosis	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT05538819	The Effects of Glimepiride in Patients With Type 2 Diabetes and Chronic Heart Failure	Glimepiride	Not Available	Not Available	completed
NCT01168362	Korea Atherosclerosis Study-3	No drug interventions	Not Available	Not Available	completed
NCT00901355	Predictive Values of Blood Pressure and Arterial Stiffness in Institutionalized Very Aged Population	No drug interventions	Not Available	Not Available	completed
NCT03218020	Red Meat, Increased Iron Load and CVD Risk	No drug interventions	Not Available	Not Available	completed
NCT01443780	Intervention With Selenium and Q10 on Cardiovascular Mortality and Cardiac Function in the Elderly Population in Sweden	No drug interventions	prevention	Not Available	completed
NCT03389529	the Change of Cholesterol Efflux Capacity and Coronary Artery Disease in Real Clinical Practice	No drug interventions	Not Available	Not Available	unknown_status
NCT06545799	Construction of a Cohort for Pan-Vascular Disease Among Employees of Taizhou People's Hospital	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT00651222	Influence of Hormone Therapy on Heart Attack Incidence in Men Undergoing Prostate Brachytherapy	No drug interventions	Not Available	Not Available	completed
NCT03654157	ACS Registry - A Non-interventional Study to Estimate the Rates of Outcomes in ACS Patients in Moscow	No drug interventions	Not Available	Not Available	completed
NCT05331547	BioFreedom™ BA9™ Ultra	No drug interventions	Not Available	Not Available	unknown_status
NCT01859897	A Prospective Multicenter Study to Evaluate Usefulness of Cardio-Ankle Vascular Index in Japan	No drug interventions	Not Available	Not Available	completed
NCT06583161	Emulation of the Moderate Alcohol and Cardiovascular Health Trial (MACH15)	No drug interventions	Not Available	Not Available	completed
NCT03939624	Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors and Risk of Cardiovascular Events	No drug interventions	Not Available	Not Available	completed
NCT01225562	Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin	Ticagrelor	prevention	3	completed