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Citalopram Mechanism of Action Action Pathway New
smpdb.ca/view/SMP0126506Drug actionCitalopram is a selective serotonin reuptake inhibitor used to manage symptoms of depression, anxiety, mood and eating disorders. Off-label indications include but are not limited to: treatment of sexual dysfunction, post-stroke behavior...
Paroxetine Mechanism of Action Action Pathway New
smpdb.ca/view/SMP0126510Drug actionParoxetine is a selective serotonin reuptake inhibitor. It is used to manage major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric dis...
Sertraline Mechanism of Action Action Pathway New
smpdb.ca/view/SMP0126512Drug actionSertraline is a selective serotonin reuptake inhibitor (SSRI) indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual ...
Mesoridazine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126524Drug actionMesoridazine, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer and a first generation typical antipsychotic. Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reti...
Thioridazine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126560Drug actionThioridazine is a trifluoro-methyl phenothiazine derivative. Thioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal...
Dosulepin Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126779Drug actionDosulepin is indicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required. Dosulepin displays affinity towards α2-adrenoceptors and to a lesser extent, α1-adrenoceptors. Inhibition of ...
Flibanserin Serotonin Action Action Pathway
smpdb.ca/view/SMP0126786Drug actionFlibansetrin has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin binds equally to 5-HT1A and 5-HT2A receptors. However, under higher levels of brain 5-...
Granisetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126787Drug actionGranisetron is a selective inhibitor of type 3 serotonergic (5-HT3) receptors. Granisetron has little or no affinity for other serotonin receptors, including 5-HT 1 , 5-HT 1A , 5-HT 1B/C , or 5-HT 2 ; for alpha 1 -, alpha 2 -, or beta-ad...
Quetiapine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126799Drug actionQuetiapine is used in the symptomatic treatment of schizophrenia. In addition, it may be used for the management of acute manic or mixed episodes in patients with bipolar I disorder, as a monotherapy or combined with other drugs. It may ...
Lorpiprazole Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126822Drug actionLorpiprazole is a serotonin antagonist and reuptake inhibitor thus, its activity is performed by antagonizing the 5-HT2A and the 5-HT2C serotoninergic receptors as well as the alpha1 and alpha2 adrenergic receptors, H1 histaminergic rece...