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Anastrozole
go.drugbank.com/drugs/DB01217ApprovedInvestigationalAnastrozole is a non-steroidal aromatase inhibitor (AI), similar to letrozole, used to decrease circulating estrogen levels in the treatment of postmenopausal women with estrogen-responsive breast cancer. Anastrozole is also related to e...
Products: KEYFENOxitriptan
go.drugbank.com/drugs/DB02959ApprovedInvestigationalNutraceuticalWithdrawn5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and metabolic intermediate in the synthesis of serotonin and melatonin. 5-HTP is sold over-the-counter in … Several double-blind placebo-controlled clinical trials have demonstrated the effectiveness of 5-HTP in the treatment of depression, though a lack of high quality studies has been noted.
Synonyms: 5-HTP, L-5-HTPPiroxicam
go.drugbank.com/drugs/DB00554ApprovedInvestigationalA cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its lon...
Products: VERAN-D, VERAN D® CAPSULAS 20 MG4-hydroxy-tetrahydrodipicolinate reductase
go.drugbank.com/bio_entities/BE0001983TargetMycobacterium tuberculosisCatalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, with NADH being 6-fold as effective as NADPH.
Synonyms: HTPA reductase4-hydroxy-tetrahydrodipicolinate synthase
go.drugbank.com/bio_entities/BE0001460TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
Synonyms: HTPA synthase4-hydroxy-tetrahydrodipicolinate reductase
go.drugbank.com/bio_entities/BE0001986TargetEscherichia coli (strain K12)Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. Can use both NADH and NADPH as a reductant, with NADH being twice as effective as NADPH.
Synonyms: HTPA reductaseATP-dependent protease ATPase subunit HslU
go.drugbank.com/bio_entities/BE0003289TargetShigella flexneriATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. Hsl...
Synonyms: htpIKetoconazole
go.drugbank.com/drugs/DB01026ApprovedInvestigationalKetoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increa...
Products: KOFENDegenerative Joint Disease of Hip
go.drugbank.com/conditions/DBCOND0110588Synonyms: OA hips, Hips osteoarthritisSEC14-like protein 2
go.drugbank.com/bio_entities/BE0000256TargetTransporterCarrierHumansCarrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrieno...
Synonyms: hTAP