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A disintegrin and metalloproteinase with thrombospondin motifs 13
go.drugbank.com/bio_entities/BE0009336EnzymeTargetHumansCleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 13T-cell immunoreceptor with Ig and ITIM domains
go.drugbank.com/bio_entities/BE0010742TargetHumansIn turn, inhibits PI3K and MAPK signaling cascades (PubMed:23154388). … In addition, associates with beta-arrestin-2/ARRB2 to recruit SHIP1/INPP5D that suppresses autoubiquitination of TRAF6 and subsequently inhibits NF-kappa-B signaling pathway (PubMed:24817116).
Polypeptides: T-cell immunoreceptor with Ig and ITIM domainsSynonyms: V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3A disintegrin and metalloproteinase with thrombospondin motifs 5
go.drugbank.com/bio_entities/BE0003730TargetHumansMetalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. … Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties.
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 5Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 11Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containing
go.drugbank.com/bio_entities/BE0004305TargetGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)Polypeptides: Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containingMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
go.drugbank.com/bio_entities/BE0009519TargetHumansMay be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380)
Polypeptides: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinaseSignal transducer and activator of transcription 1-alpha/beta
go.drugbank.com/bio_entities/BE0010099TargetHumansand STAT2. … Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors (PubMed:12764129, PubMed:12855578,
Polypeptides: Signal transducer and activator of transcription 1-alpha/betaDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
go.drugbank.com/bio_entities/BE0003558TargetHumansCatalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148) … Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539).
Polypeptides: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11ASynonyms: cAMP and cGMP phosphodiesterase 11AAnkyrin repeat and protein kinase domain-containing protein 1
go.drugbank.com/bio_entities/BE0009411TargetHumansPolypeptides: Ankyrin repeat and protein kinase domain-containing protein 1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
go.drugbank.com/bio_entities/BE0000631TargetHumansMay play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447) … Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:17389385, PubMed:27058447).
Polypeptides: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
go.drugbank.com/bio_entities/BE0002203TargetHumansPolypeptides: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2