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A disintegrin and metalloproteinase with thrombospondin motifs 13

Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation

T-cell immunoreceptor with Ig and ITIM domains

Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D … In turn, inhibits PI3K and MAPK signaling cascades (PubMed:23154388).

A disintegrin and metalloproteinase with thrombospondin motifs 5

Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. … Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties.

Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containing

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380) … Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210

Signal transducer and activator of transcription 1-alpha/beta

It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a … The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426, PubMed:35568036).

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148) … Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539).

Ankyrin repeat and protein kinase domain-containing protein 1

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447) … Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:17389385, PubMed:27058447).

2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2