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Midazolam Action Pathway
smpdb.ca/view/SMP0125055Drug actionMidazolam is administered in a variety of ways including intravenous and intramuscular injection and as a buccal solution, … anticonvulsant activity, and anxiolytic action.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Bromazepam Action Pathway
smpdb.ca/view/SMP0125070Drug actionBromazepam is a lipophilic, long-acting benzodiazepine and with sedative, hypnotic, anxiolytic and skeletal muscle relaxant properties. It does not possess any antidepressant qualities. … Bromazepam, like other benzodiazepines, presents a risk of abuse, misuse, and dependence.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Zolpidem Action Pathway (New)
smpdb.ca/view/SMP0125072Drug actionThis binding will result in an increase on the GABA inhibitory effects which is translated as an increase in the flow of chloride ions into the cell causing hyperpolarization and stabilization of the cellular … Zolpidem binding to the GABAA receptor chloride channel macromolecular complex is thought to lead to the sedative, anticonvulsant, anxiolytic, and myorelaxant drug effects of the drug.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Triazolam Action Pathway
smpdb.ca/view/SMP0126116Drug actionThese receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. … Benzodiazepines bind nonspecifically to BNZ1, which acts on sleep, and BNZ2, which acts on muscle relaxation, anticonvulsant activity, motor coordination, and memory.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Chlordiazepoxide Action Pathway
smpdb.ca/view/SMP0126120Drug actionSome side effects of using chlordiazepoxide may include drowsiness, dizziness, and weakness. … The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Chlordiazepoxide · Calcium · Magnesium cation +3 moreEnzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Flurazepam Action Pathway
smpdb.ca/view/SMP0126129Drug actionusers to drive safely and increase risks of falls and hip fractures. … Some side effects of using flurazepam may include drowsiness, dizziness, headache, and nausea.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Butalbital Action Pathway
smpdb.ca/view/SMP0126149Drug actionButalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. … Typically indicated to manage tension (or muscle contraction) headaches, butalbital is often combined with one or more therapeutic agents, such as acetylsalicylic acid, acetaminophen, aspirin, and caffeine
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Flumazenil Action Pathway
smpdb.ca/view/SMP0126152Drug actionSome side effects of using flumazenil may include headache, dizziness, nausea, and flushing. … Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Halothane GABA(A) Anesthetic Action Pathway
smpdb.ca/view/SMP0126161Drug actionIt also acts as an NMDA receptor antagonist, inhibits nACh and voltage-gated sodium channels, and activates 5-HT3 and twin-pore K+ channels. … It can be found under the brand name Fluothane and the exact mechanism of the action of general anaesthetics has not been delineated. Halothane activates GABAA and glycine receptors.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Sevoflurane GABA(A) Anesthetic Action Pathway
smpdb.ca/view/SMP0126170Drug actionIt can be found under the brand names Sevorane, Sojourn, and Ultane. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. … The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2