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Pyruvate Dehydrogenase Deficiency (E3)
smpdb.ca/view/SMP0000550DiseaseDihydrolipoamide dehydrogenase deficiency, which is also known as DLDD, DLD, E3 deficiency, pyruvate dehydrogenase E3 deficiency, DLD deficiency, E3-deficient maple syrup urine disease, is a rare inherited inborn error of metabolism. DLD...
Enzymes: Citrate synthase, mitochondrialJoubert Syndrome
smpdb.ca/view/SMP0000582DiseaseJoubert syndrome is a condition in which brain development is not completed as it should be, including the lack or underdevelopment of the part of the brain that regulates balance and coordination and an abnormal brain stem. The symptoms...
Gemcitabine Metabolism Pathway (old)
smpdb.ca/view/SMP0000603Drug metabolismGemcitabine is a cytidine analogue used in the treatment of certain cancers. Gemcitabine enters the cell via sodium nucleoside co-transporters (SLC29A1, SLC28A1, and SLC28A3), where it acts through multiple mechanisms to produce a cytoto...
Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Action Pathway
smpdb.ca/view/SMP0125166Drug actionNorepinephrine is a sympathomimetic that is regularly found to be the primary neurotransmitter in postganglionic neurons. When taken pharmacologically it acts on the sympathetic nervous system in the heart and the blood vessels. It is ma...
Joubert Syndrome
smpdb.ca/view/SMP0125809DiseaseJoubert syndrome is a condition in which brain development is not completed as it should be, including the lack or underdevelopment of the part of the brain that regulates balance and coordination and an abnormal brain stem. The symptoms...
Isradipine Action Pathway (New)
smpdb.ca/view/SMP0126295Drug actionIsradipine is a dihydropyridine calcium channel blocker used for the treatment of hypertension. Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structura...
Nifedipine Action Pathway (New)
smpdb.ca/view/SMP0126297Drug actionNifedipine is a dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension. It can be found under the brand names Adalat, Afeditab CR, Nifediac, Nifedical, and Procardia....
Nitrendipine Action Pathway (New)
smpdb.ca/view/SMP0126301Drug actionNitrendipine is a dihydropyridine calcium channel blocker indicated in the treatment of arterial hypertension. Nitrendipine is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differ...
Flunarizine Calcium Channel Artery Dilation Action Pathway
smpdb.ca/view/SMP0126303Drug actionFlunarizine is a selective calcium-entry blocker used as migraine prophylaxis in patients with severe and frequent episodes who have not responded adequately to more common treatments. Flunarizine is a selective calcium entry blocker wit...
Cyclandelate Action Pathway
smpdb.ca/view/SMP0126311Drug actionCyclandelate is a vasodilator used for the treatment of various blood vessel diseases, such as claudication and arteriosclerosis. A direct-acting smooth muscle relaxant used to dilate blood vessels. It may cause gastrointestinal distress...