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Displaying results 191 - 200 of 359 in total
  1. Pathway

    Methamphetamine Dopamine Reuptake Inhibitor Action Pathway

    smpdb.ca/view/SMP0125231
    Drug action

    Once in the brain it acts on dopamine, norepinephrine, and serotonin neurological pathways.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin +9 more
  2. Pathway

    Bupropion Action Pathway

    smpdb.ca/view/SMP0125268
    Drug action

    Norepinephrine is synthesized in the locus ceruleus from dopamine which is catalyzed by Dopamine beta-hydroxylase into norepinephrine. … Norepinephrine is released into the synapse where it accumulates because bupropion is weakly inhibiting the sodium-dependent noradrenaline receptor which prevents norepinephrine from re-entering the presynaptic

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · ATP · Norepinephrine · Dopamine +8 more
  3. Drug

    Lortalamine

    go.drugbank.com/drugs/DB09187
    Experimental

    Lortalamine (LM-1404) is a selective norepinephrine reuptake inhibitor developed in the 1980s. … This drug never made it past clinical trials, likely due to ocular toxicity in animals, but has been used in positron emission tomography studies to label norepinephrine transporters.

  4. Pathway

    Solriamfetol Action Pathway

    smpdb.ca/view/SMP0126346
    Drug action

    Solriamfetol, also known as Sunosi, is a dopamine and norepinephrine reuptake inhibitor (DNRI). … Solriamfetol weakly binds to dopamine and norepinephrine transporters but not serotonin transporters.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · ATP · Norepinephrine · Dopamine +8 more
  5. Pathway

    Safinamide Action Pathway

    smpdb.ca/view/SMP0126696
    Drug action

    The first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … The second one, the B isoform, breakdowns phenylethylamine, norepinephrine, epinephrine, dopamine, and tyramine. This isoform is found in the extracellular tissues and mostly in the brain.

    Drugs: Pyridoxal phosphate · Ademetionine · Tyrosine · ATP · Sapropterin · Norepinephrine +9 more
  6. Drug

    Phenmetrazine

    go.drugbank.com/drugs/DB00830
    ApprovedIllicit

    A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine.

  7. Drug

    Esmolol

    go.drugbank.com/drugs/DB00187
    ApprovedInvestigationalWithdrawn

    Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine.

  8. Pathway

    Levodopa Metabolism Pathway

    smpdb.ca/view/SMP0125329
    Metabolic

    Levodopa is an oral drug used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. It is a dopamine precursor and is used to synthesize dopamine in dopam...

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · NADH · Norepinephrine · Epinephrine +6 more
  9. Drug

    Quetiapine

    go.drugbank.com/drugs/DB01224
    ApprovedInvestigational

    Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of a...

  10. Drug

    Benzatropine

    go.drugbank.com/drugs/DB00245
    ApprovedInvestigational

    presence of a chlorine substituent in the para position in one of the phenyl rings produces an increased potency for dopamine uptake inhibition as well as a decreased inhibition of serotonin and norepinephrine