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Displaying results 1991 - 2000 of 8974 in total
  1. Drug

    Setmelanotide

    go.drugbank.com/drugs/DB11700
    ApprovedInvestigational

    [A224449] Earlier attempts at agonizing MC4R (such as LY2112688) lead to successful weight loss, but also an increase in blood pressure and heart rate. … Setmelanotide is the first available treatment for patients with pro-opiomelanocortin, proprotein subilisin/kexin type 1, or leptin deficiencies.

  2. Drug

    Ioxitalamic acid

    go.drugbank.com/drugs/DB13444
    ApprovedWithdrawn

    [A33006] Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem Canada Inc and approved by Health Canada in 1995. … [A27209] It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of 1500-1800 mOsm/kg.

    Categories: Compounds used in a research, industrial, or household setting
  3. Drug

    Motixafortide

    go.drugbank.com/drugs/DB14939
    ApprovedInvestigational

    [A261476] Motixafortide was approved by the FDA in September 2023, in combination with filgrastim, for use in stem cell mobilization prior to autologous stem cell transplant in patients with multiple … [L48141] It has also been investigated alongside [pembrolizumab] for the treatment of pancreatic cancer.[A261481]

  4. Drug

    Zonisamide

    go.drugbank.com/drugs/DB00909
    ApprovedInvestigational

    [L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors … [L42530,L42535] Zonisamide represents an alternative for patients that remain refractory to established antiepileptic drugs. In 1989, it was approved for commercial use in Japan.

    Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Compounds used in a research, industrial, or household setting
  5. Drug

    Mirvetuximab soravtansine

    go.drugbank.com/drugs/DB12489
    ApprovedInvestigational

    [L50306] In October 2024, it was approved in the EU for the same indication. [L52640] … linker to the genotoxic compound DM4 (also known as soravtansine or ravtansine).

  6. Drug

    Lincomycin

    go.drugbank.com/drugs/DB01627
    ApprovedInvestigationalVet approved

    [A190621] Clinical use of lincomycin has largely been superseded by its semisynthetic derivative [clindamycin] due to its higher efficacy and a wider range of susceptible organisms, though lincomycin remains … [A190657, A190621] Lincomycin was approved by the FDA on December 29, 1964.[L33214]

    Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseProducts: UTO LINCOMYCIN
  7. Indication

    Lice of the body

    go.drugbank.com/conditions/DBCOND0024507
    Drugs: Piperonyl butoxide
    Synonyms: Pediculosis due to Pediculus humanus corporis
  8. Drug

    Isocarboxazid

    go.drugbank.com/drugs/DB01247
    Approved

    [T115] It was first introduced by Roche pharmaceuticals, further developed by Validus pharms Inc and first FDA approved as a prescription drug on July 1st, 1959.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Antidepressive Agents Indicated for Depression
  9. Indication

    Erectile Dysfunction

    go.drugbank.com/conditions/DBCOND0029956
    Drugs: Alprostadil · Avanafil · Sildenafil · Tadalafil · Udenafil · Vardenafil
    Synonyms: Inability to achieve or maintain erection
  10. Indication

    Psychosis

    go.drugbank.com/conditions/DBCOND0020753
    Drugs: Aripiprazole · Benperidol · Chlorprothixene · Fluphenazine · Fluspirilene · Haloperidol +10 more
    Synonyms: Unspecified Psychosis Not Due to a Substance or Known Physiological Condition