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Difenoxin
go.drugbank.com/drugs/DB01501ApprovedIllicitDifenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. … Motofen(R) is a brand mixture which combines atropine sulfate and difenoxin hydrochloride. It is approved by the FDA to treat acute and chronic diarrhea.
Synonyms: 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotic acidCategories: Heterocyclic Compounds, 1-RingAzathioprine Action Pathway
smpdb.ca/view/SMP0000427Drug actionAzathioprine is a purine antimetabolite prodrug that exerts cytotoxic effects via three mechanisms: via incorporation of thiodeoxyguanosine triphosphate into DNA and thioguanosine triphosphate into RNA, inhibition of de novo synthesis of...
Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +27 moreEnzymes: Thiopurine S-methyltransferaseMercaptopurine Action Pathway
smpdb.ca/view/SMP0000428Drug actionMercaptopurine is a purine antimetabolite prodrug that exerts cytotoxic effects via three mechanisms: via incorporation of thiodeoxyguanosine triphosphate into DNA and thioguanosine triphosphate into RNA, inhibition of de novo synthesis ...
Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +26 moreEnzymes: Thiopurine S-methyltransferaseAluminum chloride
go.drugbank.com/drugs/DB11081ApprovedInvestigationalAluminum chloride is a chemical compound with the chemical formula AlCl3. When contaminated with iron chloride, it often displays a yellow color compared to the white pure compound. … It may also be found in over-the-counter as an antiperspirant or prescription products as an antihemorrhagic agent.
Categories: Compounds used in a research, industrial, or household settingProducts: Hemox A, Ms HemostaticAnakinra
go.drugbank.com/drugs/DB00026ApprovedInvestigationalThis drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta. … A few studies have evaluated the use of anakinra for the treatment of coronavirus disease 2019 (COVID-19).
Synonyms: Interleukin-1 receptor antagonist anakinraCategories: Interleukin-1 Receptor AntagonistPoloxamer 188
go.drugbank.com/drugs/DB11333ApprovedP188 was originally approved by the FDA in the 1960s as a therapeutic agent to reduce viscosity in the blood before transfusions, however it is no longer available in any approved products [A27217]. … There is an evidence of P188 increasing the structural stability and resealing of the plasma membrane via direct incorporation into the phospholipid bilayer [A27217].
International brands: Lutrol FCategories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A InhibitorsNitrous acid
go.drugbank.com/drugs/DB09112ApprovedInvestigationalIt is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. … Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning.
Categories: Compounds used in a research, industrial, or household settingVerteporfin
go.drugbank.com/drugs/DB00460ApprovedInvestigationalIt is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. … oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds with 4 or More RingsProducts: VISUDYNE INFÜZYON SOLÜSYONU İÇİN TOZ, 1 ADETIrbesartan
go.drugbank.com/drugs/DB01029ApprovedInvestigational[L7456,L7459] It can also be used as part of a combination product with [hydrochlorothiazide] for patients not well controlled or not expected to be well controlled on monotherapy. … Irbesartan is an angiotensin receptor blocker (ARB) indicated to treat hypertension or diabetic nephropathy.
Synonyms: 2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-oneMixtures: IRBESARTAN E IDROCLOROTIAZIDE EG, IRBESARTAN E IDROCLOROTIAZIDE EGFezolinetant
go.drugbank.com/drugs/DB15669ApprovedInvestigational[A259601] Although the pathophysiology of VMS is not fully understood, unpredictable fluctuation in estrogen levels is thought to be the main cause of VMS, as estrogen therapy has been one of the most … [A259606] Estrogen is a potent neuromodulator, particularly in the hypothalamus, and has been shown to be involved as a negative regulator in generating Gonadotropin-releasing hormone (GnRH) pulse through
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates