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Displaying results 2021 - 2030 of 10000 in total
  1. Drug

    Acetyl sulfisoxazole

    go.drugbank.com/drugs/DB14033
    ApprovedVet approved

    It is often combined with erythromycin to treat acute otitis media caused by the bacteria, haemophilus influenzae [L2790]. … Sulfisoxazole acetyl competes with PABA for the bacterial enzyme, _dihydropteroate synthase_, preventing the incorporation of PABA into dihydrofolic acid, which is the precursor of folic acid.

    Categories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
  2. Drug

    Meradimate

    go.drugbank.com/drugs/DB11096
    Approved

    [T200] It is currently required to be named as meradimate in all FDA approved OTC products. Meradimate is approved by the FDA and Health Canada to be used as an ingredient in sunblocking products. … Meradimate, before known as menthyl anthranilate, is used in a maximal concentration of 5% in different products as a UV filter.

    Mixtures: Herpecin L, Herpecin LSynonyms: Menthyl-O-aminobenzoate
  3. Drug

    Amantadine

    go.drugbank.com/drugs/DB00915
    ApprovedInvestigational

    An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. … The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

    Mixtures: ROSEL-T, Innoprax-5Categories: Influenza A M2 Protein Inhibitor, Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
  4. Pathway

    Thioguanine Action Pathway (old)

    smpdb.ca/view/SMP0000430
    Drug action

    Thioguanine is a purine antimetabolite prodrug closely related to mercaptopurine and similarly inhibits purine metabolism. The thioguanine pathway is shown as a part of the mercaptopurine pathway. Thioguanine exerts cytotoxic effects via...

    Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +27 more
    Enzymes: Thiopurine S-methyltransferase
  5. Drug

    Fluoxetine

    go.drugbank.com/drugs/DB00472
    ApprovedInvestigationalVet approved

    [A181673] It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies … Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI).

    Mixtures: TARGET 3 MG /25 MG KAPSUL, 90 ADET, TARGET 6 MG /25 MG KAPSUL, 90 ADETCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, P-glycoprotein inhibitors
  6. Drug

    Lumefantrine

    go.drugbank.com/drugs/DB06708
    ApprovedInvestigational

    </i> and may be used to treat infections caused by <i>P. falciparum</i> and unidentified <i>Plasmodium</i> species, including infections acquired in chloroquine-resistant areas. … This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.

    Mixtures: KOMEFAN ® 280, ARTEMETERO Y LUMEFANTRINACategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Inhibitors
  7. Drug

    Estradiol

    go.drugbank.com/drugs/DB00783
    ApprovedInvestigationalVet approved

    [DB00977] (EE) is a synthetic form of estradiol commonly used as the estrogenic component of most combination oral contraceptive pills (OCPs). … Ethinyl estradiol is different from estradiol due to its higher biovailability and increased resistance to metabolism, rendering it more suitable for oral administration.

    Mixtures: FEMOSTON CONTI 1/5, FEMOSTON CONTI 1/5 TABLETCategories: Sex Hormones and Modulators of the Genital System, P-glycoprotein substrates
  8. Drug

    Fluoroestradiol F-18

    go.drugbank.com/drugs/DB15690
    ApprovedInvestigational

    [L14117] It is expected to be available in late 2020/early 2021.[L14117] … Fluoroestradiol F-18 is an imaging agent used with positron emission tomography (PET) to detect estrogen receptor-positive breast cancer lesions.

    Synonyms: F-18 Fes, Fes F-18
  9. Drug

    Viltolarsen

    go.drugbank.com/drugs/DB15005
    ApprovedInvestigational

    Viltolarsen is a phosphorodiamidate morpholino oligonucleotide (PMO); PMOs are oligonucleotides in which the five-membered ribofuranosyl ring is replaced with a six-membered morpholino ring, and the phosphodiester … Viltolarsen was developed by Nippon Shinyaku Co LTD and is being marketed under the name VILTEPSO™.[L15526]

  10. Drug

    Repaglinide

    go.drugbank.com/drugs/DB00912
    ApprovedInvestigational

    Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. … It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release.

    Mixtures: REPAMEF 1/1000 MG EFERVESAN TABLET, 30 ADET, REPAMEF 1/500 MG EFERVESAN TABLET, 30 ADETCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring