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Displaying results 2061 - 2070 of 3735 in total
  1. Drug

    Diamorphine

    go.drugbank.com/drugs/DB01452
    ApprovedIllicit

    Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United...

  2. Target

    ATP-binding cassette sub-family C member 8

    go.drugbank.com/bio_entities/BE0000207
    TargetTransporterHumans

    Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release. In pancreatic cells, it forms KATP channels with KCNJ11; KCNJ11 forms the channel pore while ABCC8 is requ...

    Synonyms: Sulfonylurea receptor 1
  3. Target

    Intercellular adhesion molecule 1

    go.drugbank.com/bio_entities/BE0001085
    TargetHumans

    Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124). … Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing

    Synonyms: Major group rhinovirus receptor
  4. Target

    CD27 antigen

    go.drugbank.com/bio_entities/BE0010071
    TargetHumans

    Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells (PubMed:28011863).

    Synonyms: CD27L receptor, Tumor necrosis factor receptor superfamily member 7
  5. Drug

    Pitolisant

    go.drugbank.com/drugs/DB11642
    ApprovedInvestigational

    Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy.

    Categories: Histamine-3 Receptor Antagonist/Inverse Agonist, Histamine-3 (H3) Receptor Antagonists/Inverse Agonists
  6. Drug

    Benzocaine

    go.drugbank.com/drugs/DB01086
    ApprovedInvestigational

    Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. It is commonly used for local anesthesia in many over the counter products. Benzocaine was first used for l...

    Mixtures: SUFREXAL P, PM Toothache ReliefCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  7. Drug

    Tilidine

    go.drugbank.com/drugs/DB13787
    Investigational

    Mixtures: TILIDIN 100/8 RETARD 1A PH, TILIDIN 100/8 RETARD 1A PHCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  8. Target

    Nectin-4

    go.drugbank.com/bio_entities/BE0009798
    TargetHumans

    Does not act as receptor for alpha-herpesvirus entry into cells

    Synonyms: Ig superfamily receptor LNIR, Poliovirus receptor-related protein 4
  9. Target

    NKG2-A/NKG2-B type II integral membrane protein

    go.drugbank.com/bio_entities/BE0010560
    TargetHumans

    Immune inhibitory receptor involved in self-nonself discrimination. … Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions (PubMed:30860984, PubMed:9430220, PubMed:9485206, PubMed:9486650).

    Synonyms: NK cell receptor A, NKG2-A/B-activating NK receptorFunction: HLA-E specific inhibitory MHC class Ib receptor activity
  10. Drug

    4-O-Demethylpenclomedine

    go.drugbank.com/drugs/DB06331
    Experimental