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Elapegademase
go.drugbank.com/drugs/DB14712ApprovedIt can be defined molecularly as a genetically modified bovine adenosine deaminase with a modification in cysteine 74 for serine and with about 13 methoxy polyethylene glycol chains bound via carbonyl … group in alanine and lysine residues.
Synonyms: (74-SERINE (C>S),245-THREONINE (A>T))BOS TAURUS ADENOSINE DEAMINASE (BOVINE ADENOSINE AMINOHYDROLASE, EC=3.5.4.4)-(1-356)-PEPTIDE PRODUCED IN ESCHERICHIA COLI, AN AVERAGE OF 13 RESIDUES ARE SUBSTITUTED, AN AVERAGE OFAPPROXIMATELY 13 .OMEGA.Ganaxolone
go.drugbank.com/drugs/DB05087ApprovedInvestigational[L41130] It was approved under the brand name ZTALMY by the US FDA in March 2022 for the treatment of seizures associated with CDKL5 deficiency disorder (CDD), becoming the first FDA-approved treatment … [L41135] In July 2023, ganaxolone was also approved under the same brand name and for the same indication by the EMA.[L47636]
Categories: Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive ModulatorG protein-coupled receptor kinase 3
go.drugbank.com/bio_entities/BE0000018TargetHumansSuch receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:21799898, PubMed:33859231). … Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (PubMed:21799898).
Polypeptides: G protein-coupled receptor kinase 3Synonyms: Beta-adrenergic receptor kinase 2Vascular endothelial growth factor receptor 1
go.drugbank.com/bio_entities/BE0000029TargetHumansTyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival
Polypeptides: Vascular endothelial growth factor receptor 1Synonyms: Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptorSigma non-opioid intracellular receptor 1
go.drugbank.com/bio_entities/BE0000156TargetHumansFunctions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of d...
Polypeptides: Sigma non-opioid intracellular receptor 1Synonyms: Sigma1-receptor, Sigma 1-type opioid receptorScavenger receptor class B member 1
go.drugbank.com/bio_entities/BE0000189TargetTransporterHumansReceptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). … Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579).
Polypeptides: Scavenger receptor class B member 1Synonyms: Collagen type I receptor, thrombospondin receptor-like 1Platelet-derived growth factor receptor beta
go.drugbank.com/bio_entities/BE0000205TargetHumansReceptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor … Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development
Polypeptides: Platelet-derived growth factor receptor betaSynonyms: Beta platelet-derived growth factor receptor, Platelet-derived growth factor receptor 1Neuronal acetylcholine receptor subunit alpha-10
go.drugbank.com/bio_entities/BE0000411TargetHumansComponent of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits. E...
Polypeptides: Neuronal acetylcholine receptor subunit alpha-10Synonyms: Nicotinic acetylcholine receptor subunit alpha-10Putative gonadotropin-releasing hormone II receptor
go.drugbank.com/bio_entities/BE0000472TargetHumansPutative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional
Polypeptides: Putative gonadotropin-releasing hormone II receptorSynonyms: GnRH II receptor, Type II GnRH receptorRetinoic acid receptor responder protein 1
go.drugbank.com/bio_entities/BE0000653TargetHumansInhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle
Polypeptides: Retinoic acid receptor responder protein 1