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Displaying results 2091 - 2100 of 10000 in total
  1. Drug

    Gadoxetic acid

    go.drugbank.com/drugs/DB08884
    ApprovedInvestigational

    Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug. … Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection.

    Categories: Compounds used in a research, industrial, or household setting
  2. Drug

    Vanzacaftor

    go.drugbank.com/drugs/DB18373
    ApprovedInvestigational

    [L52275,A179677] Vanzacaftor was first approved by the US FDA in December 2024 in combination with another CFTR corrector - [tezacaftor], which binds to a different site than vanzacaftor - and [deutivacaftor … It is used alongside other CFTR correctors and CFTR potentiators to increase the quantity and function of CFTR at the cell surface in patients with cystic fibrosis.

  3. Drug

    Flortaucipir F-18

    go.drugbank.com/drugs/DB14914
    ApprovedInvestigational

    [A203933] It is used as a marker in positron emission tomography (PET) imaging of patients suspected of having Alzheimer's disease. … It was approved by the FDA on May 28, 2020, for sale by Avid Radiopharmaceuticals under the name TAUVID™ and is the first FDA-approved molecule for imaging aggregated tau protein in the brain.[L14114]

    Categories: Compounds used in a research, industrial, or household setting
  4. Drug

    Ocrelizumab

    go.drugbank.com/drugs/DB11988
    ApprovedInvestigational

    It was later approved by Health Canada in August 2017, making the drug the first available treatment for PPMS in both the US and Canada. … [A31741] In September 2024, a formulation of ocrelizumab containing [hyaluronidase (human recombinant)] was approved by the US FDA.

  5. Target

    G protein-coupled receptor kinase 3

    go.drugbank.com/bio_entities/BE0000018
    TargetHumans

    Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:21799898, PubMed:33859231). … Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (PubMed:21799898).

    Polypeptides: G protein-coupled receptor kinase 3Synonyms: Beta-adrenergic receptor kinase 2
  6. Target

    Vascular endothelial growth factor receptor 1

    go.drugbank.com/bio_entities/BE0000029
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival

    Polypeptides: Vascular endothelial growth factor receptor 1Synonyms: Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor
  7. Target

    Sigma non-opioid intracellular receptor 1

    go.drugbank.com/bio_entities/BE0000156
    TargetHumans

    Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of d...

    Polypeptides: Sigma non-opioid intracellular receptor 1Synonyms: Sigma1-receptor, Sigma 1-type opioid receptor
  8. Target

    Scavenger receptor class B member 1

    go.drugbank.com/bio_entities/BE0000189
    TargetTransporterHumans

    Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). … Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579).

    Polypeptides: Scavenger receptor class B member 1Synonyms: Collagen type I receptor, thrombospondin receptor-like 1
  9. Target

    Platelet-derived growth factor receptor beta

    go.drugbank.com/bio_entities/BE0000205
    TargetHumans

    Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor … Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development

    Polypeptides: Platelet-derived growth factor receptor betaSynonyms: Beta platelet-derived growth factor receptor, Platelet-derived growth factor receptor 1
  10. Target

    Neuronal acetylcholine receptor subunit alpha-10

    go.drugbank.com/bio_entities/BE0000411
    TargetHumans

    Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits. E...

    Polypeptides: Neuronal acetylcholine receptor subunit alpha-10Synonyms: Nicotinic acetylcholine receptor subunit alpha-10