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Displaying results 2091 - 2100 of 3735 in total
  1. Drug

    Declopramide

    go.drugbank.com/drugs/DB06421
    Experimental

  2. Drug

    Amrubicin

    go.drugbank.com/drugs/DB06263
    Investigational

    Amrubicin is a third-generation synthetic anthracycline currently in development for the treatment of small cell lung cancer. Pharmion licensed the rights to Amrubicin in November 2006. In 2002, Amrubicin was approved and launched for sa...

  3. Drug

    Dronabinol

    go.drugbank.com/drugs/DB00470
    ApprovedIllicitInvestigational

    The endocannabinoid system is widely distributed throughout the central and peripheral nervous system (via the Cannabinoid Receptors CB1 and CB2) and plays a role in many physiological processes such as … While both CBD and THC are used for medicinal purposes, they have different receptor activity, function, and physiological effects.

    Categories: Cannabinoid Receptor Agonists, P-glycoprotein inhibitors
  4. Target

    Beta-galactosidase

    go.drugbank.com/bio_entities/BE0009999
    TargetEnzymeHumans

    Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans

    Synonyms: Elastin receptor 1
  5. Drug

    Tezepelumab

    go.drugbank.com/drugs/DB15090
    ApprovedInvestigational

    Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling. Thymic stromal lymphopoietin (TSLP), an innate...

  6. Target

    C-type lectin domain family 14 member A

    go.drugbank.com/bio_entities/BE0005467
    TargetHumans

    Synonyms: Epidermal growth factor receptor 5
  7. Drug

    Galantamine

    go.drugbank.com/drugs/DB00674
    ApprovedInvestigational

    It also acts as an allosteric modulator of the nicotinic receptor, giving its dual mechanism of action clinical significance.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  8. Target

    Vitamin B12 transporter BtuB

    go.drugbank.com/bio_entities/BE0001470
    TargetTransporterEscherichia coli (strain K12)

    Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space (PubMed:4579869). It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.

    Synonyms: Cobalamin receptor
  9. Target

    Neuropilin-1

    go.drugbank.com/bio_entities/BE0002129
    TargetHumans

    Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799) … Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system.

    Synonyms: Vascular endothelial cell growth factor 165 receptor
  10. Target

    T-cell surface glycoprotein CD3 zeta chain

    go.drugbank.com/bio_entities/BE0003458
    TargetHumans

    When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z.

    Synonyms: T-cell receptor T3 zeta chain