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Pivmecillinam
go.drugbank.com/drugs/DB01605ApprovedInvestigationalPivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. … It is active against gram-negative organisms and used as for amdinocillin. [PubChem]
Categories: Heterocyclic Compounds, 2-RingSQ-109
go.drugbank.com/drugs/DB05186InvestigationalCurrently in Phase I clinical trials, SQ-109 could replace one or more drugs in the current first-line TB drug regimen, simplify therapy, and shorten the TB treatment regimen. … SQ-109 is an orally active, small molecule antibiotic for treatment of pulmonary TB.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 SubstratesSynonyms: N-adamantanyl-N'-geranyl-ethylenediamineFosgemcitabine palabenamide
go.drugbank.com/drugs/DB15057InvestigationalNUC-1031 is under investigation in clinical trial NCT03610100 (Acelarin First Line Randomised Pancreatic Study).
Categories: Heterocyclic Compounds, 1-RingSynonyms: L-ALANINE, N-(2'-DEOXY-2',2'-DIFLUORO-P-PHENYL-5'-CYTIDYLYL)-, PHENYLMETHYL ESTER, N-[[P(S)]-2'-deoxy-2',2'-difluoro-P-phenyl-5'-cytidylyl]-L-alanine phenylmethyl esterTralokinumab
go.drugbank.com/drugs/DB12169ApprovedInvestigationalWhile AD is a heterogenous condition with a variety of apparent genetic and environmental causes,[A242422] it is primarily driven by the pro-inflammatory cytokine interleukin-13 (IL-13). … US in December 2021.
Amiodarone Action Pathway (New)
smpdb.ca/view/SMP0122646Drug actionIn the presence of amiodarone, K+ accumulates in the cell since the potassium channels are blocked by amiodarone.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Dofetilide Action Pathway
smpdb.ca/view/SMP0126189Drug actionIn the presence of dofetilide, K+ accumulates in the cell since the potassium channels are blocked by the drug (rectifier potassium current). … This drug is used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Ajmaline Action Pathway
smpdb.ca/view/SMP0126271Drug actionThe drug has been very popular in some countries for the treatment of atrial fibrillation in patients with the Wolff–Parkinson–White syndrome and in well tolerated monomorphic ventricular tachycardias. … An alkaloid found in the root of Rauwolfia serpentina, among other plant sources.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Propafenone Action Pathway
smpdb.ca/view/SMP0126275Drug actionThe electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. … Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Quinidine Action Pathway (New)
smpdb.ca/view/SMP0126282Drug actionA phenomenon known as “quinidine syncope” was first described in the 1950s, characterized by syncopal attacks and ventricular fibrillation in patients treated with this drug. … This alkaloid was first described in 1848 and has a long history as an antiarrhythmic medication.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Carbamoylcholine
go.drugbank.com/drugs/DB00411ApprovedCarbamoylcholine, also known as carbachol, is a muscarinic agonist discovered in 1932. … Carbamoylcholine was granted FDA approval on 28 September 1972.[L30245]
Categories: Compounds used in a research, industrial, or household settingProducts: Isopto Carbachol 3%, MIOSTAT %0.01 İNTRAOKÜLER ÇÖZELTİ (1 ADET)