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Bamlanivimab
go.drugbank.com/drugs/DB15718ApprovedInvestigationalfor progressing to severe COVID-19:[L40179] this EUA later expanded in December 2021 to include all younger children at high risk, including newborns. … [L40174] The EUA currently allows bamlanivimab and etesevimab for post-exposure prophylaxis of COVID-19 in adults and children.[L40179]
Categories: Experimental Unapproved Treatments for COVID-19Edoxaban
go.drugbank.com/drugs/DB09075ApprovedInvestigationalBy inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. … Traditionally, warfarin, a vitamin K antagonist, was used for stroke prevention in these individuals but effective use of this drug is limited by it's delayed onset, narrow therapeutic window, need for
Didanosine
go.drugbank.com/drugs/DB00900ApprovedInvestigationalDidanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative … This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseGlipizide
go.drugbank.com/drugs/DB01067ApprovedInvestigational[L6712] Because sulfonylureas require functional pancreatic beta cells for their therapeutic effectiveness, sulfonylureas are more commonly used for early-stage type 2 diabetes when there is no progressed … [A179488] Compared to other members of the sulfonylurea drug group, glipizide displays rapid absorption and onset of action with the shortest half-life and duration of action, reducing the risk for long-lasting
Ramipril
go.drugbank.com/drugs/DB00178ApprovedInvestigationalRamiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). … Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys.
Categories: Antihypertensive Agents Indicated for HypertensionAllergic Rhinitis (AR)
go.drugbank.com/conditions/DBCOND0053380Drugs: Ambrosia artemisiifolia pollen · Amidephrine · Azelastine · Brompheniramine · Budesonide · Carbinoxamine +34 moreSynonyms: Allergic rhinitis due to allergenCentral Diabetes Insipidus
go.drugbank.com/conditions/DBCOND0051168Drugs: DesmopressinSynonyms: Diabetes insipidus secondary to vasopressin deficiencyInfections
go.drugbank.com/conditions/DBCOND0024541Drugs: Acetic acid · Ampicillin · Bacitracin · Benzamidine · Calcium hypochlorite · Chlorhexidine +18 moreSynonyms: Disease due to infectionDexmethylphenidate
go.drugbank.com/drugs/DB06701ApprovedInvestigationalThe d-isomer is thought to have greater effect with fewer side effects than the l-isomer or the racemic mixture[A177181]. … It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181].
Categories: Psychostimulants, Agents Used for ADHD and Nootropics, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeModafinil
go.drugbank.com/drugs/DB00745ApprovedInvestigationalThe exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular … Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil.
Categories: Psychostimulants, Agents Used for ADHD and Nootropics