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Thymalfasin
go.drugbank.com/drugs/DB04900InvestigationalThymalfasin is a chemically synthesized version of thymosin alpha 1 that is identical to human thymosin alpha 1. Thymosin alpha 1 is an acetylated polypeptide. … Thymosin alpha 1 is now approved in 35 developing countries for the treatment of Hepatitis B and C. It is also used to boost the immune response in the treatment of other diseases.
Synonyms: Thymosin α-1, Thymosin alpha 1Primaquine
go.drugbank.com/drugs/DB01087ApprovedInvestigationalIt has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. … An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: 6-Methoxy-8-(4-amino-1-methylbutylamino)quinoline, 8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinolineCoal tar
go.drugbank.com/drugs/DB11082ApprovedIt has been indicated for local relief of itching, dryness, and irritation caused by psoriasis, seborrhea and eczema. … Coal tar is a brown or black liquid of extremely high viscosity. Coal tar is among the by-products when coal is carbonized to make coke or gasified to make coal gas.
Mixtures: P&s Plus, X-seb T ShampooProducts: Ionil T Plus Shampoo 2%, Neutrogena T/gel Shp 2%Aripiprazole lauroxil
go.drugbank.com/drugs/DB14185ApprovedD2 receptors have been the most common target for antipsychotic agents used in the treatment of schizophrenia: the positive symptoms are thought to arise from overactivity in the mesolimbic dopaminergic … It is a prodrug of [aripiprazole], which acts as a partial agonist at the D2 and 5-HT1A receptors, and as an antagonist at the 5-HT2A receptors [A34289].
Categories: Adrenergic alpha-1 Receptor Antagonists, Serotonin 5-HT2 Receptor AntagonistsCapivasertib
go.drugbank.com/drugs/DB12218ApprovedInvestigationalbrand name TRUQAP, was approved by the FDA for the treatment of adult patients HR-positive, HER2-negative locally advanced or metastatic breast cancer with one or more alterations in PIK3CA/AKT1/PTEN gene … Therefore, significant research has been put into developing genetically targeted treatments.
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsTranscrocetinate
go.drugbank.com/drugs/DB05974InvestigationalVitamin A-analog that increases diffusivity of oxygen in aqueous solutions, including plasma.
Synonyms: 8,8'-diapo-ψ,ψ-carotenedioic acidCategories: Compounds used in a research, industrial, or household settingPigment epithelium-derived factor
go.drugbank.com/bio_entities/BE0009068TargetHumansNeurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins...
Synonyms: Cell proliferation-inducing gene 35 proteinAlpha-1-antichymotrypsin
go.drugbank.com/bio_entities/BE0009090TargetHumansAlthough its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2
Synonyms: Cell growth-inhibiting gene 24/25 proteinGlycerol-3-phosphate dehydrogenase, mitochondrial
go.drugbank.com/bio_entities/BE0010904TargetHumansCalcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device
Synonyms: mitochondrial glycerophosphate dehydrogenase geneTryptophan
go.drugbank.com/drugs/DB00150ApprovedInvestigationalNutraceuticalWithdrawnIt is a precursor of indole alkaloids in plants. It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precursor to niacin, albeit inefficiently, in mammals.
Synonyms: L-β-3-indolylalanine, (2S)-2-amino-3-(1H-indol-3-yl)propanoic acidMixtures: AMINOSTERIL N-HEPA 8%, AMINOPLASMAL® 10% E