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Trovafloxacin
go.drugbank.com/drugs/DB00685ApprovedWithdrawnTrovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. … Due to its hepatotoxic potential, trovafloxacin was withdrawn from the market.
Categories: 4-Quinolones, Heterocyclic Compounds, 2-RingGadoquatrane
go.drugbank.com/drugs/DB33282Approvedto use the lowest gadolinium dose sufficient to image a patient. … Gadoquatrane is a macrocyclic gadolinium-based contrast agent used to enhance magnetic resonance imaging.
Meprobamate
go.drugbank.com/drugs/DB00371ApprovedIllicit(From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Meprobamate is a controlled substance in the U.S. … It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines.
Estradiol acetate
go.drugbank.com/drugs/DB13952ApprovedVet approvedEstradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. … Estradiol acetate is commercially available as Femring, a vaginal ring used for the treatment of moderate to severe vasomotor symptoms and vulvovaginal atrophy due to menopause.
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP1A1 SubstratesSynonyms: Estradiol 3-acetate, Estradiol-3-acetateEphedra sinica root
go.drugbank.com/drugs/DB01363ApprovedNutraceuticalThe sale of ephedra-containing supplements intended to increase muscle weight or promote weight loss was banned in the United States in 2004 due to the risk for adverse effects and a lack of evidence for … Ephedra is an alkaloid chemical compound traditionally obtained from the plant _Ephedra sinica_.
Mixtures: Miller's Formula No. 1Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Adrenergic alpha-2 Receptor AgonistsTelmisartan
go.drugbank.com/drugs/DB00966ApprovedInvestigationalGenerally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular … smooth muscle, ultimately leading to a reduction in arterial blood pressure.
Mixtures: TELMISARTAN E IDROCLOROTIAZIDE EG, TELMISARTAN E IDROCLOROTIAZIDE EGCategories: Agents Acting on the Renin-Angiotensin System, Angiotensin 2 Receptor BlockerThonzylamine
go.drugbank.com/drugs/DB11235ApprovedThonzylamine is an antihistamine and anticholinergic drug. … It is available as combination products with [DB04837] or [DB00388] for temporary relief of symptoms of common cold, hay fever (allergic rhinitis) or other upper respiratory allergies.
Mixtures: Nasopen PECategories: Heterocyclic Compounds, 1-RingAminohippuric acid
go.drugbank.com/drugs/DB00345ApprovedInvestigationalWithdrawnThe glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. [PubChem]
Categories: Compounds used in a research, industrial, or household settingSynonyms: N-(p-Aminobenzoyl)glycine, N-(p-Aminobenzoyl)aminoacetic acidAducanumab
go.drugbank.com/drugs/DB12274ApprovedInvestigationalAducanumab, or BIIB037, is a monoclonal IgG1 antibody that targets extracellular amyloid-β plaques in the brain; similar to [gantenerumab], [bapineuzumab] and [solanezumab]. … [L34420] Biogen enrolled patients in phase 3 clinical trials in 2015 but increased the size of the trials from 1350 patients to 1650 patients to maintain statistical power in the face of a high standard
Samidorphan
go.drugbank.com/drugs/DB12543ApprovedInvestigational[A235638, A235643] Samidorphan was first approved as a variety of fixed-dose combination tablets with [olanzapine] by the FDA on May 28, 2021, and is currently marketed under the trademark LYBALVI™ … may be expected to ameliorate these negative effects.
Salts: Samidorphan L-malateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates