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Displaying results 2171 - 2180 of 8696 in total
  1. Drug

    HSD-016

    go.drugbank.com/drugs/DB12419
    Investigational

    Hsd 016 is under investigation in clinical trial NCT00838461 (Study Evaluating the Safety, Pharmacokinetics (PK), and Pharmacodynamices (PD) of HSD-016).

  2. Drug

    Lepirudin

    go.drugbank.com/drugs/DB00001
    ApprovedWithdrawn

    [A246609] Bayer ceased the production of lepirudin (Refludan) effective May 31, 2012.[L41574] … [L41539] Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence of sulfate on the tyrosine residue at position 63 and the substitution of leucine for isoleucine

  3. Drug

    Mephentermine

    go.drugbank.com/drugs/DB01365
    ApprovedWithdrawn

    Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. … It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia.

    Categories: Adrenergic alpha-1 Receptor Agonists
  4. Drug

    Hydrochlorothiazide

    go.drugbank.com/drugs/DB00999
    ApprovedInvestigationalVet approved

    [A185138] Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.

    Mixtures: Mar-candesartan / Hctz, Mar-candesartan / HctzCategories: Antihypertensive Agents Indicated for Hypertension
  5. Drug

    Inosine

    go.drugbank.com/drugs/DB04335
    Approved

    It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules.

  6. Drug

    Licorice

    go.drugbank.com/drugs/DB10675
    Approved

    Licorice allergenic extract is used in allergenic testing.

    Mixtures: NELLCO SPECIAL OBH PE, HAN SHIN GAMKONAL Extract Granules
  7. Drug

    Sparsentan

    go.drugbank.com/drugs/DB12548
    ApprovedInvestigational

    Furthermore, it is the first non-immunosuppressive therapy for the reduction of proteinuria in IgAN.[L45315] The use of sparsentan may cause hepatotoxicity and embryo-fetal toxicity. … [L45300,L45315] In September 2024, it was granted full approval for an expanded indication.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  8. Target

    Prostaglandin E2 receptor EP1 subtype

    go.drugbank.com/bio_entities/BE0000064
    TargetHumans

    Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. … May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues

    Polypeptides: Prostaglandin E2 receptor EP1 subtypeSynonyms: PGE receptor EP1 subtype, Prostanoid EP1 receptor
  9. Target

    Retinoic acid receptor RXR-beta

    go.drugbank.com/bio_entities/BE0000078
    TargetHumans

    Receptor for retinoic acid.

    Polypeptides: Retinoic acid receptor RXR-betaSynonyms: Retinoid X receptor beta, Nuclear receptor subfamily 2 group B member 2
  10. Target

    Glutamate receptor ionotropic, kainate 1

    go.drugbank.com/bio_entities/BE0000346
    TargetHumans

    L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. … The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist

    Polypeptides: Glutamate receptor ionotropic, kainate 1Synonyms: Glutamate receptor 5, Excitatory amino acid receptor 3