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Displaying results 2211 - 2220 of 8696 in total
  1. Target

    C5a anaphylatoxin chemotactic receptor 1

    go.drugbank.com/bio_entities/BE0010095
    TargetHumans

    Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, … The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events

    Polypeptides: C5a anaphylatoxin chemotactic receptor 1Synonyms: C5a anaphylatoxin chemotactic receptor
  2. Target

    Interferon alpha/beta receptor (IFNAR)

    go.drugbank.com/bio_entities/BE0010136
    TargetHumans

    Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:2153461 … Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity)

    Polypeptides: Interferon alpha/beta receptor 1, Interferon alpha/beta receptor 2Synonyms: IFN-alpha/beta receptor 1, IFN-alpha/beta receptor 2
  3. Target

    Interleukin-1 receptor-like 2

    go.drugbank.com/bio_entities/BE0010198
    TargetHumans

    Receptor for interleukin-36 (IL36A, IL36B and IL36G). … After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways

    Polypeptides: Interleukin-1 receptor-like 2Synonyms: IL-36 receptor, Interleukin-1 receptor-related protein 2
  4. Target

    Interleukin-7 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0010557
    TargetHumans

    Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP)

    Polypeptides: Interleukin-7 receptor subunit alphaSynonyms: IL-7 receptor subunit alpha
  5. Target

    Sphingosine 1-phosphate receptor 2

    go.drugbank.com/bio_entities/BE0012208
    TargetHumans

    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617, PubMed:25274307). … Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity).

    Polypeptides: Sphingosine 1-phosphate receptor 2Synonyms: S1P receptor 2, S1P receptor Edg-5
  6. Target

    N-formyl peptide receptor 2

    go.drugbank.com/bio_entities/BE0012843
    TargetHumans

    Differential signaling is also defined by receptor oligomerization state. … Pattern recognition G protein-coupled receptor (GPCR) that recognizes peptides with N-terminal formyl methionine, which are derived from invading pathogens or host mitochondria as pathogen or damage-associated

    Polypeptides: N-formyl peptide receptor 2Synonyms: LXA4 receptor, Lipoxin A4 receptor
  7. Drug

    Paramethadione

    go.drugbank.com/drugs/DB00617
    Approved

    Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Substrates
  8. Drug

    Lorpiprazole

    go.drugbank.com/drugs/DB09195
    Approved

    Lorpiprazole is a serotonin antagonist and reuptake inhibitor used for the treatment of major depressive disorder.[A31634] It is a piperazinyl-triazole derivative.[T83]

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates
  9. Drug

    Diphenylpyraline

    go.drugbank.com/drugs/DB01146
    Approved

    Diphenylpyraline is an antihistamine. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells.

    Categories: Antihistamines for Systemic Use
  10. Drug

    Miocamycin

    go.drugbank.com/drugs/DB13287
    Approved

    This drug may be marketed in Japan for clinical use as it is listed in the Japanese pharmacopeia [L5737]. … It has shown to be effective against several gram-positive and gram-negative microbes and may be useful in the treatment of upper and lower respiratory tract infections, and urogenital tract infections

    Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic Use