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Displaying results 221 - 230 of 10000 in total
  1. Drug

    Insulin glulisine

    go.drugbank.com/drugs/DB01309
    Approved

    If left untreated, the body starts to break down fat, instead of glucose, for energy which results in a build-up of ketone acids in the blood and a syndrome called ketoacidosis, which is a life-threatening … Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.

    Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersProducts: Apidra SoloStar 100 Units/ml Solution for injection in a pre-filled pen, APIDRA SOLOSTAR 100 UNITS/ML, SOLUTION FOR INJECTION IN A PRE-FILLED PEN
  2. Drug

    Ixekizumab

    go.drugbank.com/drugs/DB11569
    ApprovedInvestigational

    Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. … In particular, IL-17A has been found to be implicated in a variety of autoimmune diseases including Rheumatoid Arthritis and plaque psoriasis.

    Products: Taltz 80mg solution for injection in pre-filled pen, TALTZ SOLUTION FOR INJECTION IN PRE-FILLED PEN 80 mg/ml
  3. Target

    Apolipoprotein E

    go.drugbank.com/bio_entities/BE0001119
    TargetCarrierHumans

    APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (PubMed:14754908, PubMed:1911868, PubMed:6860692)....

    Polypeptides: Apolipoprotein ESynonyms: Apo-E
  4. Target

    Carboxypeptidase E

    go.drugbank.com/bio_entities/BE0001123
    EnzymeTargetHumans

    Sorting receptor that directs prohormones to the regulated secretory pathway. Also acts as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after ini...

    Polypeptides: Carboxypeptidase E
  5. Pathway

    Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126428
    Drug action

    Verapamil acts on smooth muscles and cardiac muscles. … Verapamil, known as the brand names Calan, Isoptin, Tarka, and Verelan, is a non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension.

    Drugs: Verapamil · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  6. Drug

    Peginterferon alfa-2a

    go.drugbank.com/drugs/DB00008
    ApprovedInvestigational

    When combined together, Peginterferon alfa-2a and [DB00811] have been shown to achieve a SVR between 36% for genotype 1 and 59% for genotypes 2-6 after 48 weeks of treatment. … -2a for the treatment of Hepatitis C [A19593].

    Categories: Compounds used in a research, industrial, or household setting, peginterferon alfa-2aSynonyms: PEG-IFN alfa-2A, PEG-Interferon alfa-2A
  7. Drug

    Mepolizumab

    go.drugbank.com/drugs/DB06612
    ApprovedInvestigational

    Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm<sup>3</sup> or more) is associated with a spectrum … [A221048, A221053, A221058, A221063, A221068, L16518] Mepolizumab is a fully-humanized recombinant IgG1 kappa monoclonal antibody directed against IL-5 produced in Chinese hamster ovary cells.

    Categories: Interleukin-5 AntagonistProducts: NUCALA SOLUTION FOR INJECTION IN PRE-FILLED PEN 100MG/ML, Nucala 100mg/ml Solution for Injection in pre-filled pen (Autoinjector)
  8. Target

    Extended-spectrum beta-lactamase PER-1

    go.drugbank.com/bio_entities/BE0008647
    TargetPseudomonas aeruginosa

    Polypeptides: Extended-spectrum beta-lactamase PER-1
  9. Drug

    Dulaglutide

    go.drugbank.com/drugs/DB09045
    ApprovedInvestigational

    Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct … therapy to diet and exercise in the management of 2 diabetes (T2DM).

    Categories: Glucagon-like peptide-1 (GLP-1) analogues, GLP-1 AgonistsProducts: Trulicity 1.5mg solution for injection in pre-filled pen, Trulicity 0.75mg solution for injection in pre-filled pen
  10. Drug

    Tetracaine

    go.drugbank.com/drugs/DB09085
    ApprovedInvestigationalVet approved

    Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch.

    Mixtures: Lidocaine 7% / Tetracaine 7%, Ndc 72934- 5010-4 Benzocaine 20% / Lidocaine 8% / Tetracaine 4%.Synonyms: Diäthylaminoäthanol ester der p-butylaminobenzösäure, 2-(dimethylamino)ethyl 4-(butylamino)benzoate