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Displaying results 2291 - 2300 of 10000 in total

Drug
Haloprogin
go.drugbank.com/drugs/DB00793
ApprovedWithdrawn
Haloprogin is no longer available in the United States and has been discontinued. … Haloprogin is used as a topical ointment or cream in the treatment of Tinea infections.
Categories: Antifungals for Topical Use, Antifungals for Dermatological Use
Drug
Sodium stibogluconate
go.drugbank.com/drugs/DB05630
ApprovedInvestigational
Sodium stibogluconate is sold in the UK as Pentostam (manufactured by GlaxoSmithKline). … Sodium stibogluconate is a medicine used to treat leishmaniasis and is only available for administration by injection. It belongs to the class of medicines known as the pentavalent antimonials.
Drug
Tridihexethyl
go.drugbank.com/drugs/DB00505
ApprovedWithdrawn
Tridihexethyl is an antimuscarinic, anticholinergic drug. Tridihexethyl is no longer available in the US market. … Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract.
Categories: Drugs for Functional Gastrointestinal Disorders
Drug
Fostamatinib
go.drugbank.com/drugs/DB12010
ApprovedInvestigational
It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, L52150]. Fostamatinib has also been granted orphan drug status by the FDA [L2644]. … Recently, fostamatinib has been identified as a potential therapeutic for controlling acute respiratory distress syndrome (ARDS) in patients with severe COVID-19 through its ability to modulate the SYK
Categories: Experimental Unapproved Treatments for COVID-19
Drug
Etoperidone
go.drugbank.com/drugs/DB09194
ApprovedWithdrawn
Etoperidone is an atypical antidepressant introduced in Europe in 1977. … It is a phenylpiperazine-substituted triazole derivative with a composition that classifies it as an analog of tradozone and presents a similar pharmacological profile.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
Drug
Castor oil
go.drugbank.com/drugs/DB11113
ApprovedNutraceuticalVet approved
Castor oil was mainly used in the manufacturing of soaps, lubricants, and coatings [A31170]. It is an FDA-approved food additive directly added to food products for human consumption. … Castor oil is a rich source of [DB02955], which represents up to 90% of the total castor oil content.
Categories: Drugs for ConstipationSynonyms: Toto ni vavalagi oil
Drug
Egg phospholipids
go.drugbank.com/drugs/DB14233
ApprovedWithdrawn
Egg phospholipids are available as an intravenous fat emulsion indicated as a source of calories for patients requiring parenteral nutrition.
Mixtures: LIPOFUNDIN N EMULSION FOR INFUSION 20 %, KABIVEN EMULSION FOR INFUSION
Drug
Retapamulin
go.drugbank.com/drugs/DB01256
Approved
Retapamulin, marketed by GlaxoSmithKline as the ointment Altabax, is an antibiotic for skin infections like impetigo. It was approved by the FDA in April 2007.
Categories: Antibiotics for Topical Use
Drug
Agomelatine
go.drugbank.com/drugs/DB06594
ApprovedInvestigational
In 2006 Servier sold the rights to develop Agomelatine in the US to Novartis. The development for the US market was discontinued in October 2011. … The Committee for Medical Products for Human Use (CHMP) recommended refusal of marketing authorization on 27 July 2006. The major concern was that efficacy had not been sufficiently shown.
Target
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
go.drugbank.com/bio_entities/BE0000571
TargetEnzymeHumans
Together with PDHB forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex (PubMed:17474719, PubMed:19081061). The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby li...
Polypeptides: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial