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Azithromycin
go.drugbank.com/drugs/DB00207ApprovedInvestigationalAzithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration [A174172]. It was initially approved by the FDA in 1991 [A174175]. … In March 2020, a small study was funded by the French government to investigate the treatment of COVID-19 with a combination of azithromycin and the anti-malaria drug [hydroxychloroquine].
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: AZITROMICINA EG, AZITROMICINA EG STADATapentadol
go.drugbank.com/drugs/DB06204ApprovedInvestigationalTapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake. … [A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA on August 26, 2011.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesSynonyms: 3-[(1R,2R)-3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol, PHENOL, 3-((1R,2R)-3-(DIMETHYLAMINO)-1-ETHYL-2-METHYLPROPYL)-Olanzapine
go.drugbank.com/drugs/DB00334ApprovedInvestigationalOlanzapine is a thienobenzodiazepine derivative and an atypical or second-generation antipsychotic agent. … [A176996] Its chemical structure contains a thieno[2,3-b][1,5]benzodiazepine core, and has a methyl group attached to the piperazine ring.
Synonyms: 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepineInternational brands: Jolyon-MDHaloperidol
go.drugbank.com/drugs/DB00502ApprovedInvestigationalIn addition, they block many receptors other than the primary target (dopamine receptors), such as cholinergic or histaminergic receptors, resulting in a higher incidence of side effects such as sedation … [A180616] While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain,[A27477] it exerts its antipsychotic effect through its strong antagonism of the dopamine receptor
Categories: Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT2 Receptor AntagonistsSynonyms: 1-(3-p-fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-oneAmoxicillin
go.drugbank.com/drugs/DB01060ApprovedInvestigationalVet approvedAmoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. … [A190648] Amoxicillin was granted FDA approval on 18 January 1974.[L11644]
Mixtures: CURAM 457 MG/ 5 ML, AUGMENTİN ES 600 MG + 42,9 MG/5 ML ORAL SÜSPANSİYON HAZIRLAMAK İÇİN KURU TOZ, 100 MLCategories: Penicillin G, Heterocyclic Compounds, 1-RingCefpodoxime
go.drugbank.com/drugs/DB01416ApprovedInvestigationalVet approvedCefpodoxime is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and Gram negative bacteria. … Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.
Mixtures: INFEX PLUS 50/62.5 MG/5 ML ORAL SUSPANSIYON HAZIRLAMAK ICIN KURU TOZ, 100 ML, INFEX PLUS 100/62.5 MG/5 ML ORAL SUSPANSIYON HAZIRLAMAK ICIN KURU TOZ, 100 MLCategories: Heterocyclic Compounds, 2-RingLisinopril
go.drugbank.com/drugs/DB00722ApprovedInvestigational[A184781,A184808,A184817] ACEIs are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers. … [A184844] Lisinopril was granted FDA approval on 29 December 1987.[L8384]
Mixtures: LISAM 10 mg/5 mg Tabletten, LisAm 20 mg/5 mg TablettenCategories: Compounds used in a research, industrial, or household setting, Agents Acting on the Renin-Angiotensin SystemSolifenacin
go.drugbank.com/drugs/DB01591ApprovedInvestigationalSolifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. … [L7511] It has a long duration of action as it is usually taken once daily.[L7511] Solifenacin was granted FDA approval on 19 November 2004.[L7511]
Mixtures: VESOMNİ 6 MG/0.4 MG DEĞİŞTİRİLMİŞ SALIMLI TABLET, 30 ADET, Vesomni 6 mg/0,4 mg Tabletten mit veränderter WirkstofffreisetzungCategories: Drugs Used in Benign Prostatic Hypertrophy, Cytochrome P-450 SubstratesIvabradine
go.drugbank.com/drugs/DB09083ApprovedInvestigationalIvabradine acts by selectively inhibiting the "funny" channel pacemaker current (If) in the sinoatrial node in a dose-dependent fashion, resulting in a lower heart rate and thus more blood to flow to the … Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus rhythm with resting heart rate
Mixtures: Implicor 50 mg/5 mg Filmtabletten, IMPLICOR FILM-COATED TABLET 50 mg/5 mgCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingBromhexine
go.drugbank.com/drugs/DB09019ApprovedInvestigationalBromhexine is mucolytic agent used for a variety of respiratory conditions associated with increased mucus secretion. … It was introduced into the market in 1963, and is widely available as an over-the-counter drug in many countries.
Mixtures: GLICERTOX N F, PENBRITIN EXSynonyms: N-cyclohexyl-N-methyl-(2-amino-3,5-dibrombenzyl)amine, 3,5-dibromo-N(alpha)-cyclohexyl-N(alpha)-methyltoluene-alpha-2-diamine