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Displaying results 2331 - 2340 of 10000 in total
  1. Drug

    Pamidronic acid

    go.drugbank.com/drugs/DB00282
    ApprovedInvestigational

    Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid].[A203111] Pamidronic acid was first described in the literature in 1977. … [A203111] Pamidronic acid was granted FDA approval on 31 October 1991.[L13835]

    Products: พามิซอล ชนิดฉีด 15 มก./5 มล., 30 มก./10 มล., PAMEX 90 MG IV INF. ICIN LIYOFILIZE TOZ ICEREN FLAKON, 1 ADET
  2. Drug

    Cetuximab

    go.drugbank.com/drugs/DB00002
    ApprovedInvestigational

    [A228083] _In vitro_, cetuximab was shown to mediate anti-tumour effects in numerous cancer cell lines and human tumour xenografts. … [A227963] EGFR is often mutated in certain types of cancer and serves as a driver of tumorigenesis.

    Products: ERBITUX ® 5 MG/ML, ERBITUX® 5 MG/ML
  3. Drug

    Epirubicin

    go.drugbank.com/drugs/DB00445
    ApprovedInvestigational

    An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.

    Synonyms: (1S,3S)-3-GLYCOLOYL-1,2,3,4,6,11-HEXAHYDRO-3,5,12-TRIHYDROXY-10-METHOXY-6,11-DIOXO-1-NAPHTHACENYL 3-AMINO-2,3,6-TRIDEOXY-.ALPHA.-L-ARABINO-HEXOPYRANOSIDE, 4'-EpiadriamycinCategories: Topoisomerase II Inhibitors, UGT2B7 Substrates with a Narrow Therapeutic Index
  4. Drug

    Atracurium

    go.drugbank.com/drugs/DB13295
    ApprovedInvestigationalWithdrawn

    Categories: Heterocyclic Compounds, 2-RingProducts: NEUCURIUM 50 MG/5 ML IV INFUZYON VE ENJEKSIYON ICIN COZELTI ICEREN AMPUL, 5 ADET, NEUCURIUM 25 MG/2.5 ML IV INFUZYON VE ENJEKSIYON ICIN COZELTI ICEREN AMPUL, 5 ADET
  5. Pathway

    The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria

    smpdb.ca/view/SMP0002358
    Disease

    shares enough structural similarity to 2-oxogluratate (2OG) to inhibit a range of 2OG-dependent dioxygenases, including histone lysine demethylases (KDMs) and the ten-eleven translocation (TET) family of 5- … This results in modulations of HIF-mediated hypoxia responses and alterations in gene expression through global epigenetic remodelling that may contribute to malignant transformation.

    Drugs: Pyruvic acid · Biotin · L-Glutamine · Succinic acid · Glutamic acid · NADH +6 more
  6. Drug

    Loxapine

    go.drugbank.com/drugs/DB00408
    ApprovedInvestigational

    An antipsychotic agent used in schizophrenia. [PubChem]

    Synonyms: 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepineCategories: Serotonin 5-HT2 Receptor Antagonists, Serotonin 5-HT2A Receptor Antagonists
  7. Drug

    Morphine

    go.drugbank.com/drugs/DB00295
    ApprovedInvestigational

    Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805.[A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. … Morphine was granted FDA approval in 1941.[L12114]

    Synonyms: (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol, (5α,6α)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diolCategories: Cytochrome P-450 Substrates, P-glycoprotein substrates
  8. Drug

    Fentanyl

    go.drugbank.com/drugs/DB00813
    ApprovedIllicitInvestigationalVet approved

    Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. … [A179542] In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths).[L6748] Opioid overdoses kill an average of 11 Canadians daily.

    Synonyms: N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide, N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamideMixtures: Innovar Inj
  9. Drug

    Rifamycin

    go.drugbank.com/drugs/DB11753
    ApprovedInvestigationalWithdrawn

    The parent compound of rifamycin was rifamycin B which was originally obtained as a main product in the presence of diethylbarburitic acid. … [L4800] This drug was also sent for review to the EMA in 2015 by Dr. Falk Pharma Gmbh and it was granted a waiver for the tested conditions.[L4801]

    Mixtures: RIFOCIN 125 MG+5 MG/1,5 ML IM ENJEKSİYON İÇİN SOLÜSYON İÇEREN AMPUL, 100 ADET, RIFOCIN 125 MG+5 MG/1,5 ML IM ENJEKSİYON İÇİN SOLÜSYON İÇEREN AMPUL, 1 ADETCategories: MATE 1 Inhibitors, P-glycoprotein inhibitors
  10. Drug

    Methylprednisolone

    go.drugbank.com/drugs/DB00959
    ApprovedInvestigationalVet approved

    Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone].[A188811] It was first described in the literature in the late 1950s. … [A192813] The efficacy of methylprednisolone in novel coronavirus pneumonia is being investigated further in clinical trials.[L12666]

    Synonyms: 1-dehydro-6α-methylhydrocortisone, delta(1)-6alpha-MethylhydrocortisoneMixtures: Physicians EZ Use M-pred, Physicians EZ Use M-pred